Outcome of traumatic brain injury after three decades - Relationship to ApoE genotype
Outcome of traumatic brain injury after three decades - Relationship to ApoE genotype
复制标题
DOI：
10.1089/neu.2006.23.1600
复制
发表时间：
2006-11-01
影响因子：
4.2
通讯作者：
Kairisto, Veli
中科院分区：
文献类型：
--
作者：
Isoniemi, Heli;Tenovuo, Olli;Kairisto, Veli
严重的创伤性脑损伤（TBI）几乎总是与认知缺陷相关，但以高度可变的方式。载脂蛋白E （ApoE）在中枢神经系统对损伤的反应中起关键作用。为了研究ApoE基因型与TBI患者长期预后的关系，我们确定了61名30多年前受伤的TBI患者的ApoE基因型。所有患者均在损伤后进行神经心理学研究。通过反复的神经心理学测试和各种日常功能和生活质量的测量来评估长期结果。30年后，携带ApoE e4等位基因的TBI患者的一般认知水平明显低于没有该等位基因的患者。这种下降完全是由于这些患者中有一个亚组出现了偶发性或临床痴呆，而大多数ApoE e4阳性患者根本没有出现下降。描述职业、身体或主观症状结果的其他结果测量没有显示与ApoE基因型有显著关系。一部分携带ApoE e4等位基因的TBI患者似乎有长期认知能力下降的风险。
Significant traumatic brain injury (TBI) is nearly always associated with cognitive deficits, but in a highly variable manner. Apolipoprotein E (ApoE) plays a pivotal role in CNS response to injury. To examine the association of ApoE genotype with long-term outcome in TBI patients, we determined the ApoE genotype from 61 TBI patients who had been injured over three decades earlier. All patients had been studied neuropsychologically after their injuries. The long-term outcome was evaluated with repeated neuropsychological testing and by applying various measures of everyday functioning and quality of life. After three decades, TBI patients with the ApoE e4 allele showed significantly poorer general cognitive level than those without this allele. This decline was wholly accounted for by a subgroup of these patients who had developed incident or clinical dementia, while the majority of the ApoE e4 positive patients showed no decline at all. The other outcome measures describing vocational, physical, or subjective symptom outcome did not show significant relationships to the ApoE genotype. A portion of the TBI patients with the ApoE e4 allele seem to be at risk of long-term cognitive decline.