A NOVEL FRIEDEL-CRAFTS REACTION - SYNTHESIS OF 4-PHENYLNAPHTHALEN-1-OLS
A NOVEL FRIEDEL-CRAFTS REACTION - SYNTHESIS OF 4-PHENYLNAPHTHALEN-1-OLS
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DOI：
10.1021/jo00015a049
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发表时间：
1991-07-19
影响因子：
3.6
通讯作者：
WATANABE, KA
中科院分区：
文献类型：
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作者：
HUANG, JT;SU, TL;WATANABE, KA
几种苯衍生物（3b-d）与琥珀酰氯（方案I）在低温下反应，得到相应的内酯（5 b-d，17-50%）作为主要产物，沿着少量的1，2-双（苯甲酰基）-乙烷（6 b-f，0.6-9%）。应该注意的是，当在-5 ℃下进行相同的反应时，我们分离出5 b作为主要产物（50%）沿着6d（8%）。在非常相似的条件下（唯一的区别是温度，为0 ℃）。Baker等10在23%中获得了6d
Reaction of several benzene derivatives (3b-d) with succinyl chloride (Scheme I) at low temperature afforded the corresponding lactones (5b-d, 17-50%) as the major product, along with small amounts of l, 2-bis (benzoyl)-ethanes (6b—f, 0.6-9%). It should be noted that we iso-lated 5b as a major product (50%) along with 6d (8%) when the same reaction was carried out at-5 eC. Under very similar conditions (only difference was the tempera-ture, which was 0 C). Baker et al. 10 obtained 6d in 23%