Use of the dry eye questionnaire to measure symptoms of ocular irritation in patients with aqueous tear deficient dry eye
Use of the dry eye questionnaire to measure symptoms of ocular irritation in patients with aqueous tear deficient dry eye
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DOI：
10.1097/00003226-200210000-00007
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发表时间：
2002-10-01
期刊：
影响因子：
2.8
通讯作者：
Mitchell, GL
中科院分区：
文献类型：
--
作者：
Begley, CG;Caffery, B;Mitchell, GL
目的。目的：探讨干眼症问卷(DEQ)对干燥综合征(SS)、干性角结膜炎(KCS)患者和年龄匹配的对照组眼表症状的频度和日间强度的影响。方法：研究方法。来自多伦多西医院的100名泪水缺乏性干眼症患者被邮寄了DEQ和McMonnies问卷(MQ)。年龄和性别匹配的对照是从历史数据集中选择的。DEQ测量了常见眼表症状的习惯性频率、强度和影响，并询问了有关电脑使用、药物和过敏的问题。结果。62名干眼症患者有反应；30名接受SS治疗，32名接受KCS治疗。与对照组相比，SS患者报告的症状频率和强度最高，其次是非KCS患者。SS患者除干燥和光敏感外，其余症状在晚上的症状强度均显著高于上午(p<；0.05)。60%的SS受试者报告说，由于干燥、灼热和光敏感，需要停止日常活动并闭上眼睛。结论。SS和KCS受试者的眼刺激症状频繁而强烈。这些症状通常会随着时间的推移而加剧，这表明睁开眼睛的情况会影响症状的进展。用DEQ测量症状频率和日间强度提供了一种敏感的工具，可能在干眼的临床治疗试验中有用。
Purpose. To demonstrate the ability of the Dry Eye Questionnaire (DEQ) to characterize the frequency of ocular surface symptoms and their diurnal intensity in patients with Sjogren's syndrome (SS), keratoconjunctivitis sicca (KCS), and age-matched controls. Methods. One hundred patients with tear-deficient dry eye from Toronto Western Hospital were mailed the DEQ and the McMonnies' questionnaire (MQ). Age- and gender-matched controls were selected from an historical data set. The DEQ measured the habitual frequency, intensity, and impact of common ocular surface symptoms and asked questions about computer use, medications, and allergies. Results. Sixty-two dry eye subjects responded; 30 with SS and 32 with KCS. Compared with controls, SS subjects consistently reported the highest frequency and intensity of symptoms, followed by non-KCS subjects. The intensity of symptoms was significantly greater in the evening than in the morning among SS subjects for all symptoms except dryness and light sensitivity (p < 0.05). Sixty percent of SS subjects reported the need to stop daily activities and close their eyes due to dryness, burning, and light sensitivity. Conclusions. Symptoms of ocular irritation were frequent and intense among SS and KCS subjects. These symptoms often increased in intensity over the day, suggesting that open-eye conditions affect the progression of symptoms. Measurement of symptom frequency and diurnal intensity by the DEQ provides a sensitive tool that may be useful in clinical treatment trials for dry eye.