Influenza vaccine effectiveness in Wisconsin during the 2007-08 season: Comparison of interim and final results
Influenza vaccine effectiveness in Wisconsin during the 2007-08 season: Comparison of interim and final results
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DOI：
10.1016/j.vaccine.2011.07.002
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发表时间：
2011-09-02
期刊：
影响因子：
5.5
通讯作者：
Shay, David K.
中科院分区：
文献类型：
--
作者：
Belongia, Edward A.;Kieke, Burney A.;Shay, David K.
背景资料：在2007-08年流感季节，我们报告了一个临时的疫苗有效性（VE）估计为44%，以防止医疗照顾的流感。在这项分析中，我们报告整个赛季的结果，并将其与中期estimate.Methods：发热，寒战，咳嗽= 50岁的患者。甲型流感病毒的VE为41%（95% CI，24-53%），B流感病毒为31%（95% CI，3-51%）。所有24种特征性甲型流感病毒与H3 N2疫苗株抗原性匹配，尽管14种病毒表现出轻度抗原漂移。所有39个特征的流感B virus.Conclusions：2007-08年流感疫苗提供适度的保护，防止医疗照顾流感在这一人群中的谱系不匹配的疫苗株。17天后VE的中期估计值与最终季节VE非常接近，支持在流感季节仍在进行中时使用中期VE估计值的可能性。(C)2011爱思唯尔有限公司保留所有权利。
Background: During the 2007-08 influenza season, we reported an interim vaccine effectiveness (VE) estimate of 44% for preventing medically attended influenza. In this analysis we report results for the entire season and compare them with the interim estimate.Methods: Patients with feverishness, chills, or cough = 50 years old. VE was 41% (95% Cl, 24-53%) for influenza A and 31% (95% Cl, 3-51%) for influenza B. All 24 characterized influenza A viruses were antigenically matched to the H3N2 vaccine strain, although 14 viruses exhibited mild antigenic drift. There was a lineage mismatch with the vaccine strain for all 39 characterized influenza B viruses.Conclusions: The 2007-08 influenza vaccine provided modest protection against medically attended influenza in this population. The interim estimate of VE after 17 days closely approximated the final season VE, supporting the potential use of interim VE estimates while influenza seasons are still in progress. (C) 2011 Elsevier Ltd. All rights reserved.