Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma
Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma
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DOI：
10.1158/0008-5472.can-15-3121
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发表时间：
2016-07-15
期刊：
影响因子：
11.2
通讯作者：
Thirdborough, Stephen M.
中科院分区：
文献类型：
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作者：
Ottensmeier, Christian H.;Perry, Kate L.;Thirdborough, Stephen M.
阻断T细胞调节检查点的抗体最近已经成为癌症治疗的一种变革性方法。然而，检查点阻断的临床疗效取决于固有的肿瘤免疫原性，浸润T细胞的变化导致客观缓解率的差异。在这里，我们试图了解鳞状细胞癌（SCC）中肿瘤浸润性T淋巴细胞（TIL）的分子相关性，使用系统生物学方法将公开可用的组学数据集与组织病理学特征相结合。我们提供的证据表明，TIL丰度和治疗结果的调节肿瘤糖酵解的EGFR和HIF，这两者都是有吸引力的分子靶点，用于与免疫治疗组合。（C）2016年AACR。
Antibodies that block T-cell-regulatory checkpoints have recently emerged as a transformative approach to cancer treatment. However, the clinical efficacy of checkpoint blockade depends upon inherent tumor immunogenicity, with variation in infiltrating T cells contributing to differences in objective response rates. Here, we sought to understand the molecular correlates of tumor-infiltrating T lymphocytes (TIL) in squamous cell carcinoma (SCC), using a systems biologic approach to integrate publicly available omics datasets with histopathologic features. We provide evidence that links TIL abundance and therapeutic outcome to the regulation of tumor glycolysis by EGFR and HIF, both of which are attractive molecular targets for use in combination with immunotherapeutics. (C)2016 AACR.