Cancer core distribution in patients diagnosed by extended transperineal prostate biopsy
Cancer core distribution in patients diagnosed by extended transperineal prostate biopsy
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DOI：
10.1016/j.urology.2005.01.051
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发表时间：
2005-07-01
期刊：
影响因子：
2.1
通讯作者：
Baba, S
中科院分区：
文献类型：
--
作者：
Satoh, T;Matsumoto, K;Baba, S
目标。对既往经直肠超声引导前列腺活检阴性的患者行22核经会阴超声引导模板前列腺活检，评估癌核分布。在2001年4月至2003年12月间，128名男性采用经会阴模板技术接受了系统性超声引导活检。所有患者之前都至少做过一次活检。前列腺活检经会阴进行，使用18号活检针由弹簧加载装置驱动。中部四个冠状面前后各取4个活检组织，根尖两个冠状面前后各取3个活检组织。128例患者中，29例（22.7%）经会阴活检证实为癌症。前列腺癌患者的前列腺特异性抗原（PSA）水平（11.4比7.6 ng/mL, P = 0.0125）、过渡区体积（12.7比21.2 cm(3), P = 0.0012）、前列腺较小（31.5比44.0 cm(3), P = 0.0015）、PSA密度更高（0.36比0.19 ng/mL/cm(3), P = 0.0125）
Objectives. To perform systemic 22-core transperineal ultrasound-guided template prostate biopsies in patients with previous negative transrectal ultrasound-guided prostate biopsy findings and evaluate the cancer core distribution.Methods. Between April 2001 and December 2003, 128 men underwent systemic ultrasound-guided biopsy using the transperineal template technique. All patients had undergone at least one previous set of biopsies. Prostate biopsy was performed transperineally using an 18-gauge biopsy needle driven by a spring-loaded device. Four biopsies were obtained anterior to posterior from each of four coronal planes in the mid-region, and three biopsies were obtained anterior to posterior from each of two coronal planes in the apical region.Results. Of the 128 patients, 29 (22.7%) had cancer according to an extended transperineal biopsy. Patients with prostate cancer had significantly greater prostate-specific antigen (PSA) levels (11.4 versus 7.6 ng/mL, P = 0.0125), smaller transition zone volumes (12.7 versus 21.2 cm(3), P = 0.0012), smaller prostate glands (31.5 versus 44.0 cm(3), p = 0.0015), and greater PSA density (0.36 versus 0,19 ng/mL/cm(3), P