MRI of rabbit atherosclerosis in response to dietary cholesterol lowering.
MRI of rabbit atherosclerosis in response to dietary cholesterol lowering.
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DOI：
10.1161/01.atv.19.8.1956
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发表时间：
1999-08
期刊：
影响因子：
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通讯作者：
M. McConnell;M. Aikawa;S. Maier;P. Ganz;P. Libby;R. Lee
中科院分区：
文献类型：
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作者：
M. McConnell;M. Aikawa;S. Maier;P. Ganz;P. Libby;R. Lee
动脉粥样硬化斑块的直接成像，而不是血管造影术，可以更好地了解动脉粥样硬化对降胆固醇治疗的反应。对饮食胆固醇干预的兔主动脉斑块进行了MRI活体研究。31只兔子接受了主动脉球囊损伤和高胆固醇饮食4个月，然后被分配到低胆固醇饮食和持续高胆固醇饮食长达16个月。分别于术后4、12、20个月行高分辨率(310微米)快速自旋回波腹主动脉MRI检查，并与组织学结果进行比较。MRI显示，接受低胆固醇饮食(44.6+/-2。20个月时为1%，4个月时为55.8+/-1.5%，P=0.0002)。相比之下，高胆固醇饮食兔的面积狭窄百分比增加(20个月时为69.8+/-3.8%，4个月时为55.8+/-1.5%，P=0.001)。同样，低胆固醇组斑块厚度显著减少(20个月时为0.60+/-0.05 mm，4个月时为0.85+/-0.06 mm，P=0.006)，高胆固醇组有增加趋势(20个月时为1.02+/-0.08 mm，4个月时为0.85+/-0.06 mm，P=0.1)。因此，在饮食降低胆固醇的兔子中，MRI检测到体内主动脉粥样硬化斑块的消退。随着高胆固醇饮食的维持，斑块进展被观察到。MRI是一种很有前途的无创技术，可以直接成像动脉粥样硬化及其对治疗干预的反应。
Direct imaging of the atherosclerotic plaque, rather than the angiographic lumen, may provide greater insight into the response of atherosclerosis to cholesterol-lowering therapy. Aortic plaque was studied in vivo by MRI in rabbits undergoing dietary cholesterol intervention. Thirty-one rabbits underwent aortic balloon injury and high-cholesterol diet for 4 months and then were assigned to low-cholesterol versus continued high-cholesterol diet for up to an additional 16 months. High-resolution (310 micrometer) fast spin-echo MRI of the abdominal aorta was performed at 4, 12, and 20 months and compared with histology. MRI demonstrated a significant reduction in % area stenosis in rabbits placed on low-cholesterol diet (44.6+/-2. 1% at 20 months versus 55.8+/-1.5% at 4 months, P=0.0002). In contrast, % area stenosis increased in rabbits maintained on high-cholesterol diet (69.8+/-3.8% at 20 months versus 55.8+/-1.5% at 4 months, P=0.001). Similarly, plaque thickness decreased significantly in the low-cholesterol group (0.60+/-0.05 mm at 20 months versus 0.85+/-0.06 mm at 4 months, P=0.006), with a trend toward increase in the high-cholesterol group (1.02+/-0.08 mm at 20 months versus 0.85+/-0.06 mm at 4 months, P=0.1). Thus, in rabbits undergoing dietary cholesterol lowering, MRI detected regression of aortic atherosclerotic plaque in vivo. Plaque progression was seen with maintenance of high-cholesterol diet. MRI is a promising noninvasive technology for directly imaging atherosclerosis and its response to therapeutic interventions.