Sex differences in regional gray matter in healthy individuals aged 44-48 years: A voxel-based morphometric study
Sex differences in regional gray matter in healthy individuals aged 44-48 years: A voxel-based morphometric study
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DOI：
10.1016/j.neuroimage.2007.03.063
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发表时间：
2007-07-01
期刊：
影响因子：
5.7
通讯作者：
Anstey, Kaarin J.
中科院分区：
文献类型：
--
作者：
Chen, Xiaohua;Sachdev, Perminder S.;Anstey, Kaarin J.
这项研究检测了44-48岁健康个体的区域灰质(GM)的性别差异。从社区随机抽取411名年龄在44-48岁的受试者进行T1加权MRI扫描，并应用优化的体素形态计量学来检测男性和女性之间的局部GM差异，校正了年龄、受教育年限、利手和总颅内体积(TIV)的影响。与女性相比，男性有更大的脑体积和更高的白质(WM)与TIV比率。女性的GM与TIV比率高于男性。在控制了年龄、受教育年限、利手和TIV后，男性和女性在GM总量上没有显著差异。存在区域性性别二型性，男性在中脑、左侧颞下回、右侧枕叶舌回、右侧颞中回和双侧小脑半球的GM体积较多。女性GM多见于背侧前扣带回、后扣带回、腹侧扣带回，以及右侧顶下小叶。我们的结果表明，在中年健康个体中，GM存在性别二型性，这不太可能用脑病理来解释。这些差异可能为性别在某些认知功能上的差异提供了结构性的大脑基础。(C)2007 Elsevier Inc.保留所有权利。
The study examined sex-related differences in regional gray matter (GM) in 44-48 year old healthy individuals. T1-weighted MRI scans were acquired in 411 subjects aged 44-48 from a random community sample and optimized voxel-based morphometry was applied to detect regional GM difference between men and women, correcting for effects of age, years of education, handedness, and total intracranial volume (TIV). Men had larger brain volumes and higher white matter (WM) to TIV ratios compared with women. Women had higher GM to TIV ratios than men. After controlling for age, years of education, handedness, and TIV, there were no significant differences between men and women in the total GM volumes. Regional sex dimorphism was present, with men having more GM volume in midbrain, left inferior temporal gyros, right occipital lingual gyros, right middle temporal gyros, and both cerebellar hemispheres. Women showed more GM in dorsal anterior, posterior and ventral cingulate cortices, and right inferior parietal lobule. Our results suggest sex dimorphism in GM in middle aged healthy individuals, which is not likely to be explained by brain pathology. These differences may provide the structural brain basis for sex differences in certain cognitive functions. (c) 2007 Elsevier Inc. All rights reserved.