Functional analysis of the Aurora kinase A Ile31 allelic variant in human prostate
Functional analysis of the Aurora kinase A Ile31 allelic variant in human prostate
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DOI：
10.1593/neo.07322
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发表时间：
2007-09-01
期刊：
影响因子：
4.8
通讯作者：
Orr-Urtreger, Avv
中科院分区：
文献类型：
--
作者：
Matarasso, Noa;Bar-Shira, Anat;Orr-Urtreger, Avv
中心体相关丝氨酸/苏氨酸激酶Aurora Kinase A（AURKA）的过度表达在晚期前列腺癌和高级别前列腺上皮内瘤变病变中均已得到证实。单核苷酸多态性T91 A（Phe 31 Ile）与AURKA过表达有关，并被认为是多种人类癌症（包括前列腺癌）的低风险易感性等位基因。我们研究了28个商业正常前列腺组织RNA样本（中位年龄27岁）中AURKA Ile 31等位基因的转录结果。AURKA Ile 31前列腺RNA纯合子和杂合子中AURKA显著过表达（分别为2.07倍和1.93倍; P
Overexpression of the centrosome-associated serine/threonine kinase Aurora Kinase A ( AURKA) has been demonstrated in both advanced prostate cancer and high-grade prostatic intraepithelial neoplasia lesions. The single-nucleotide polymorphism T91A ( Phe31Ile) has been implicated in AURKA overexpression and has been suggested as a low-penetrance susceptibility allele in multiple human cancers, including prostate cancer. We studied the transcriptional consequences of the AURKA Ile31 allele in 28 commercial normal prostate tissue RNA samples ( median age, 27 years). Significant overexpression of AURKA was demonstrated in homozygous and heterozygous AURKA Ile31 prostate RNA ( 2.07-fold and 1.93-fold, respectively; P