Melanocytic Nevi and sun exposure in a cohort of Colorado children: Anatomic distribution and site-specific sunburn
Melanocytic Nevi and sun exposure in a cohort of Colorado children: Anatomic distribution and site-specific sunburn
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DOI：
10.1158/1055-9965.epi-07-0453
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发表时间：
2007-10-01
影响因子：
3.8
通讯作者：
Crane, Lori A.
中科院分区：
文献类型：
--
作者：
Dodd, Athena T.;Morelli, Joseph;Crane, Lori A.
阳光照射和黑素细胞痣的高患病率是黑色素瘤的主要危险因素，但它们之间的关系尚不清楚。这项研究调查了科罗拉多州丹佛市 743 名白人儿童的阳光照射（详细说明了解剖位置和特定部位晒伤史）与黑素细胞痣的存在之间的关系。从 5 至 6 岁开始，连续两年收集特定部位晒伤的家长报告。第三年，对痣进行计数并按解剖位置绘制地图。男孩的痣密度（36.0 痣/m(2)）高于女孩（31.0 痣/m(2)；P = 0.04）。面部、颈部和前臂外侧的痣密度最高，并且长期暴露在阳光下的区域明显高于间歇性暴露在阳光下的区域（P < 0.0001）。与女孩相比，男孩面部、颈部和躯干的痣密度较高，上臂和大腿的痣密度较低（P < 0.01）。在两年的报告中，大多数受试者 (69%) 至少经历过一次晒伤。脸部、肩膀和背部是身体最常被晒伤的部位。根据宿主因素进行调整后，晒伤总数与较高的痣总患病率显着相关（1 次烧伤 P = 0.01）。特定部位的晒伤与背部痣的患病率显着相关（3 次或以上晒伤的 P = 0.03），但与面部、手臂或腿部的痣无关。在这一高危人群中，有证据表明痣堆积有两种途径：长期暴露在阳光下和与晒伤相关的间歇性暴露。
Sun exposure and high prevalence of melanocytic nevi are major risk factors for melanoma, but the relationship between them is not well understood. This study examines the relationship between sun exposure (detailed by anatomic location and history of site-specific sunburns) and the presence of melanocytic nevi on 743 White children in Denver, Colorado. Parental reports of site-specific sunburns were collected annually for 2 years starting at ages 5 to 6 years. In the third year, nevi were counted and mapped by anatomic location. Nevus density was higher for boys (36.0 nevi/m(2)) than for girls (31.0 nevi/m(2); P = 0.04). Nevus density was highest on the face, neck, and lateral forearms and was significantly higher in chronically versus intermittently sun-exposed areas (P < 0.0001). Compared with girls, boys had higher nevus density on the face, neck, and trunk, and lower nevus density on the upper arms and thighs (P < 0.01). In 2 years of reports, most subjects (69%) received at least one sunburn. The face, shoulders, and back were the most frequently sunburned areas of the body. When adjusted for host factors, total number of sunburns was significantly associated with higher total nevus prevalence (P = 0.01 for one burn). Site-specific sunburns were significantly associated with nevus prevalence on the back (P = 0.03 for three or more sunburns), but not on the face, arms, or legs. In this high-risk population, there is evidence for two pathways to nevus accumulation: by chronic sun exposure and by intermittent exposure related to sunburns.