Expression of a novel secreted factor, Seraf indicates an early segregation of Schwann cell precursors from neural crest during avian development.
Expression of a novel secreted factor, Seraf indicates an early segregation of Schwann cell precursors from neural crest during avian development.
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Seraf 是一种新型分泌因子的表达，表明施万细胞前体在鸟类发育过程中与神经嵴早期分离。
DOI：
10.1016/j.ydbio.2003.12.014
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Weston,JamesA
中科院分区：
文献类型：
--
作者：
Wakamatsu,Yoshio;Osumi,Noriko;Weston,JamesA
神经嵴在周围神经系统中产生神经胶质细胞。在外周神经胶质中，雪旺细胞形成髓鞘，通常包裹外周轴突。与其他嵴源性细胞谱系如神经元相比，雪旺细胞的命运决定和随后的分化的分析还没有很好地进展，部分原因是缺乏这种表型的早期标志物。在这项研究中，我们已经确定了一个基因，独特的表达在鸟类胚胎雪旺细胞前体，它编码一种新的分泌因子，命名为Seraf（雪旺细胞特异性EGF样重复自分泌因子）。Seraf和P0的表达描绘了雪旺细胞分化的最早阶段。在鸡胚神经嵴迁移过程中，Seraf与神经嵴细胞和雪旺细胞结合，影响雪旺细胞的分布。我们的研究结果表明Seraf的自分泌功能，并提供了一个重要的一步，了解雪旺细胞谱系的发育过程。
The neural crest gives rise to glial cells in the peripheral nervous system. Among the peripheral glia, Schwann cells form the myelin often wrapping the peripheral axons. Compared to other crest-derived cell lineages such as neurons, the analysis of fate determination and subsequent differentiation of Schwann cells is not well advanced, partly due to the lack of early markers of this phenotype. In this study, we have identified a gene, uniquely expressed in avian embryo Schwann cell precursors, which encodes a novel secreted factor, designated Seraf (Schwann cell-specific EGF-like repeat autocrine factor). Expression of Seraf and P0 delineates the earliest phase of Schwann cell differentiation. Seraf binds to neural crest cells and Schwann cells, and affects the distribution of Schwann cells, when introduced to chicken embryos during neural crest migration. Our results suggest an autocrine function of Seraf and provide a significant step to understand the developmental processes of Schwann cell lineage.