Phenotypic and genetic clustering of diabetes and metabolic syndrome in Chinese families with type 2 diabetes mellitus
Phenotypic and genetic clustering of diabetes and metabolic syndrome in Chinese families with type 2 diabetes mellitus
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DOI：
10.1002/dmrr.577
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发表时间：
2006-01-01
影响因子：
8
通讯作者：
Chan, JCN
中科院分区：
文献类型：
--
作者：
Li, JKY;Ng, ACY;Chan, JCN
背景本研究的目的是调查2型糖尿病（T2DM）和代谢综合征（MES）的家族性和聚集性，主要是在香港家庭糖尿病Study.Methods 179个家庭（913名受试者），通过糖尿病先证者被确定为2型糖尿病（T2DM）和代谢综合征（MES）的家庭。检查人体测量、血糖稳态、血压和血脂水平。结果140个家系（78%）中至少有1名早发性T2DM患者（确诊年龄
Background The aim of this study was to investigate the familiality and clustering of type 2 diabetes (T2DM) and metabolic syndrome (MES) predominantly in families with young-onset diabetes from the Hong Kong Family Diabetes Study.Methods One hundred and seventy-nine families (913 subjects) were ascertained through a diabetic proband. Anthropometry, glucose homeostasis, blood pressure and lipid levels were examined. Familial aggregation and inter-relationships of these traits were examined by recurrence risk ratio, heritability, genetic and environmental correlations.Results One hundred and forty families (78%) had at least one subject with early-onset T2DM (age-at-diagnosis