Larval starvation improves metabolic response to adult starvation in honey bees (Apis mellifera L.)
Larval starvation improves metabolic response to adult starvation in honey bees (Apis mellifera L.)
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DOI：
10.1242/jeb.136374
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发表时间：
2016-04
影响因子：
2.8
通讯作者：
Ying Wang;Jacob B. Campbell;O. Kaftanoğlu;R. Page;G. Amdam;J. Harrison
中科院分区：
文献类型：
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作者：
Ying Wang;Jacob B. Campbell;O. Kaftanoğlu;R. Page;G. Amdam;J. Harrison
发育过程中的环境变化对多种生物的成体表型具有长期影响。其中一些效应在帮助生物体适应不同环境方面发挥着重要作用，比如昆虫的多态性。其他的，特别是由不利的发展环境造成的，对成人的健康和体质有负面影响。然而，最近的研究表明，受早期环境逆境影响的表型在与发育环境相似的某些（预期）条件下具有适应价值，尽管证据主要来自形态和行为观察，在生理和分子水平上仍然很少。在同伴研究中，我们对5龄蜜蜂幼虫进行了短期饥饿处理，并测量了成虫形态、饥饿抗性、激素和代谢生理以及基因表达的变化。我们的研究结果表明，蜜蜂可以对预测的营养压力做出适应性反应。在本研究中，我们进一步假设发育性饥饿特异性地改善了成年蜜蜂对饥饿的代谢反应，而不是在营养充足的条件下全面影响代谢。在这里，我们培育了经历过短期幼虫饥饿的成年蜜蜂，然后我们让它们挨饿12小时，并监测代谢率、血糖浓度和代谢储备。我们发现，经历过幼虫饥饿的蜜蜂能够更快地转换到其他燃料，并在饥饿期间更好地保持稳定的血糖水平。然而，在正常条件下，发育性营养应激不会改变成年蜜蜂的代谢率或血糖水平。总之，我们的研究提供了进一步的证据，证明早期幼虫饥饿特异性地改善了蜜蜂对成年饥饿的代谢反应。摘要：蜜蜂是一种社会性昆虫，根据幼虫食物限制的经验，蜜蜂可以预先设定代谢表型以适应成虫的饥饿。
ABSTRACT Environmental changes during development have long-term effects on adult phenotypes in diverse organisms. Some of the effects play important roles in helping organisms adapt to different environments, such as insect polymorphism. Others, especially those resulting from an adverse developmental environment, have a negative effect on adult health and fitness. However, recent studies have shown that those phenotypes influenced by early environmental adversity have adaptive value under certain (anticipatory) conditions that are similar to the developmental environment, though evidence is mostly from morphological and behavioral observations and it is still rare at physiological and molecular levels. In the companion study, we applied a short-term starvation treatment to fifth instar honey bee larvae and measured changes in adult morphology, starvation resistance, hormonal and metabolic physiology and gene expression. Our results suggest that honey bees can adaptively respond to the predicted nutritional stress. In the present study, we further hypothesized that developmental starvation specifically improves the metabolic response of adult bees to starvation instead of globally affecting metabolism under well-fed conditions. Here, we produced adult honey bees that had experienced a short-term larval starvation, then we starved them for 12 h and monitored metabolic rate, blood sugar concentrations and metabolic reserves. We found that the bees that experienced larval starvation were able to shift to other fuels faster and better maintain stable blood sugar levels during starvation. However, developmental nutritional stress did not change metabolic rates or blood sugar levels in adult bees under normal conditions. Overall, our study provides further evidence that early larval starvation specifically improves the metabolic responses to adult starvation in honey bees. Highlighted Article: Based on the experience of larval food restriction, honey bees, a eusocial insect species, can preset metabolic phenotypes to adapt to adult starvation.