Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice.
Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice.
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手术引起的神经炎症不会损害年轻成年小鼠的参考记忆
DOI：
10.1155/2016/3271579
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发表时间：
2016
影响因子：
4.6
通讯作者：
Su D
中科院分区：
文献类型：
--
作者：
Zhao Y;Huang L;Xu H;Wu G;Zhu M;Tian J;Wang H;Wang X;Yu W;Yang L;Su D
术后认知功能障碍(POCD)增加了术后的发病率和死亡率。但其潜在机制尚不清楚。虽然年龄现在被认为是POCD的首要风险因素，但调查成人术后认知功能的研究结果一直存在争议，而且缺乏关于非常年轻的成年个体的数据。本研究观察了麻醉和手术后2月龄小鼠的空间参考记忆、IL-1β、IL-6和小胶质细胞激活的变化。结果发现，术后6h，大鼠海马区IL-1、β和IL-6水平均升高。手术后6至24小时，小胶质细胞在海马区被深度激活。然而，在这些小鼠中没有发现明显的行为变化。这些结果表明，尽管麻醉和手术导致了神经炎症，但后者不足以损害幼年成年小鼠的空间参考记忆。
Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data about the very young adult individuals are lacking. The present study investigated the spatial reference memory, IL-1β, IL-6, and microglia activation changes in the hippocampus in 2-month-old mice after anesthesia and surgery. We found that hippocampal IL-1β and IL-6 increased at 6 hours after surgery. Microglia were profoundly activated in the hippocampus 6 to 24 hours after surgery. However, no significant behavior changes were found in these mice. These results indicate that although anesthesia and surgery led to neuroinflammation, the latter was insufficient to impair the spatial reference memory of young adult mice.
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影响因子：
2.7
作者：
Bour, Alexandra;Grootendorst, Jeannette;Mathis, Chantal
通讯作者：
Mathis, Chantal
影响因子：
4.6
作者：
Theodorou, G. L.;Mouzaki, A.;Karakantza, M.
通讯作者：
Karakantza, M.
白介素-1β在术后认知功能障碍中的作用。
影响因子：
11.2
作者：
Cibelli M;Fidalgo AR;Terrando N;Ma D;Monaco C;Feldmann M;Takata M;Lever IJ;Nanchahal J;Fanselow MS;Maze M
通讯作者：
Maze M
影响因子：
11.2
作者：
Terrando N;Eriksson LI;Ryu JK;Yang T;Monaco C;Feldmann M;Jonsson Fagerlund M;Charo IF;Akassoglou K;Maze M
通讯作者：
Maze M
影响因子：
2.5
作者：
Fidalgo, Antonio Rei;Cibelli, Mario;Ma, Daqing
通讯作者：
Ma, Daqing