The utility of seroepidemiology for tracking trends in pertussis infection
The utility of seroepidemiology for tracking trends in pertussis infection
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DOI：
10.1017/s0950268809990707
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发表时间：
2010-03-01
影响因子：
4.2
通讯作者：
Gilbert, G. L.
中科院分区：
文献类型：
--
作者：
Quinn, H. E.;McIntyre, P. B.;Gilbert, G. L.
随着时间的推移和国家之间的百日咳流行病学比较被诊断和通知实践的差异所混淆。对基于人口的样本采用标准化血清学方法可提高可比性。不同水平的百日咳毒素IgG（PT IgG）抗体，标准化方法测量的人群患病率进行了比较，年龄组和地区的澳大利亚1997/1998年和2002年之间。2002年，推定近期感染百日咳的5至9岁儿童（根据IgG水平>= 62.5 ELISA单位/毫升）的比例显著下降，与同期的通知数据一致，并且在从全细胞疫苗改为无细胞疫苗后加强疫苗的接种率有所提高。相比之下，35-49岁的成年人最近的推定感染显著增加。使用标准化PT IgG抗体检测进行的以人群为基础的血清监测有可能帮助解释与疫苗规划有关的和国家之间的百日咳发病率趋势。
Comparing pertussis epidemiology over time and between countries is confounded by differences in diagnostic and notification practices. Standardized serological methods applied to population-based samples enhance comparability. Population prevalence of different levels of pertussis toxin IgG (PT IgG) antibody, measured by standardized methods, were compared by age group and region of Australia between 1997/1998 and 2002. The proportion of 5- to 9-year-olds with presumptive recent pertussis infection (based on IgG levels >= 62.5 ELISA units/ml) significantly decreased in 2002, consistent with notification data for the same period and improved uptake of booster vaccines following the schedule change from whole-cell to acellular vaccine. In contrast, recent presumptive infection significantly increased in adults aged 35-49 years. Population-based serosurveillance using standardized PT IgG antibody assays has the potential to aid interpretation of trends in pertussis incidence in relation to vaccine programmes and between countries.