FITTING OF NORMAL TISSUE TOLERANCE DATA TO AN ANALYTIC-FUNCTION
FITTING OF NORMAL TISSUE TOLERANCE DATA TO AN ANALYTIC-FUNCTION
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DOI：
10.1016/0360-3016(91)90172-z
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发表时间：
1991-05-15
影响因子：
7
通讯作者：
GOITEIN, M
中科院分区：
文献类型：
--
作者：
BURMAN, C;KUTCHER, GJ;GOITEIN, M
在外部射束放射治疗期间，正常组织与肿瘤一起沿着照射。 放射治疗师试图将正常组织的剂量最小化，同时将高剂量输送到目标体积。 通常这是困难的，并且由于正常组织的照射而引起并发症。 这些并发症不仅取决于剂量，而且取决于受照射器官的体积。 莱曼（4）提出了一个四参数经验模型，该模型可用于表示在对全部和部分体积进行均匀照射的条件下正常组织的反应，作为剂量和照射体积的函数。 在本文中，莱曼模型已被应用于Emami等人（1）开发的临床耐受性数据汇编。 已经确定了表征组织反应的四个参数，并给出了导出的概率分布的图形表示。 因此，该模型可用于内插临床数据，以提供正常组织剂量和辐照体积的任何组合和所考虑的终点的估计正常组织并发症概率。
During external beam radiotherapy, normal tissues are irradiated along with the tumor. Radiation therapists try to minimize the dose to normal tissues while delivering a high dose to the target volume. Often this is difficult and complications arise due to irradiation of normal tissues. These complications depend not only on the dose but also on volume of the organ irradiated. Lyman (4) has suggested a four-parameter empirical model which can be used to represent normal tissue response under conditions of uniform irradiation to whole and partial volumes as a function of the dose and volume irradiated. In this paper, Lyman's model has been applied to a compilation of clinical tolerance data developed by Emami et al. (1). The four parameters to characterize the tissue response have been determined and graphical representations of the derived probability distributions are presented. The model may, therefore, be used to interpolate clinical data to provide estimated normal tissue complication probabilities for any combination of dose and irradiated volume for the normal tissues and end points considered.