Critical care management of potential organ donors: our current standard
Critical care management of potential organ donors: our current standard
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DOI：
10.1111/j.1399-0012.2009.01102.x
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发表时间：
2009-12-01
影响因子：
2.1
通讯作者：
Ahmadi, R.
中科院分区：
文献类型：
--
作者：
Dictus, C.;Vienenkoetter, B.;Ahmadi, R.
照顾脑死亡的潜在器官捐献者需要将重症监护从颅内压增高的广泛治疗转向维持捐献器官功能的策略。然而，器官捐献者重症监护管理欠佳、不规范是器官采购不足的主要原因之一。脑死亡后的病理生理变化导致并发症发生率很高，包括血流动力学不稳定、内分泌和代谢紊乱，以及危及潜在可移植器官的内部稳态破坏。存在器官捐献者管理策略，其中包括使捐献者生理机能正常化。这导致了标准化工作，以改善为潜在器官捐赠者提供的重症监护。增加的不仅仅是数量。还包括合适器官的质量以及为受者提供最佳结果的目标。在这篇综述中，我们讨论了与脑死亡相关的病理生理变化，并介绍了我们部门当前的指南，这些指南是根据现有文献进行优化的。
Caring for a brain dead potential organ donor requires a shift in critical care from the extensive treatment of increased intracranial pressure towards strategies to maintain donor organ function. Suboptimal, unstandardized critical care management of organ donors, however, is one of the main reasons for insufficient organ procurement. The pathophysiological changes following brain death entail a high incidence of complications including hemodynamic instability, endocrine and metabolic disturbances, and disruption of internal homeostasis that jeopardize potentially transplantable organs. Strategies for the management of organ donors exist and consist of the normalization of donor physiology. This has resulted in standardized efforts to improve the critical care delivered to potential organ donors. increasing not Only the number. but also the quality of Suitable organs and aiming at an optimal Outcome for the recipients. In this review, we discuss the pathophysiological changes associated with brain death and present the current guidelines at our department, which are optimized based on available literature.