Oral squamous cell carcinoma - Histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival
Oral squamous cell carcinoma - Histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival
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DOI：
10.1097/01.pas.0000149687.90710.21
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发表时间：
2005-02-01
影响因子：
5.6
通讯作者：
Wang, Beverly Yiyao
中科院分区：
文献类型：
--
作者：
Brandwein-Gensler, Margaret;Teixeira, Miriam S.;Wang, Beverly Yiyao
分析切除边缘状态和组织学指标对口腔鳞状细胞癌（OSCC）患者局部复发（LR）和总生存期（OS）的影响。本研究采用回顾性和前瞻性设计。队列1是指292例OSCC患者的整个组。以探索性方式检查队列1最早切除标本的载玻片的多个参数。队列2是指未接受任何新辅助治疗且具有结局数据的203例患者的子集。队列3代表队列2（n = 168）的一个子集，其中组织学切除边缘状态可以再次确认。队列4是指85例舌/口底肿瘤患者的亚组。切缘状态指定如下：第1组，术中分析清除≥ 5 mm，无需补充切缘（n = 46）;第2组，测量初始切缘，
To analyze the impact of resection margin status and histologic prognosticators on local recurrence (LR) and overall survival (OS) for patients with oral squamous cell carcinoma (OSCC). This study was both retrospective and prospective in design. Cohort 1 refers to the entire group of 292 patients with OSCC. The slides from the earliest resection specimens from Cohort 1 were examined in an exploratory manner for multiple parameters. Cohort 2 refers to a Subset of 203 patients, who did not receive any neoadjuvant therapy and had outcome data. Cohort 3 represents a subset of Cohort 2 (n = 168) wherein the histologic resection margin status could be reconfirmed. Cohort 4 refers a Subset of 85 patients with tongue/floor of mouth tumors. Margins status was designated as follows: group 1, clearance of gtoreq5 mm with intraoperative analysis, no need for supplemental margins (n = 46); group 2, initial margins were measured as