INDUCTION OF TRUE PRECOCIOUS PUBERTY BY NEONATAL TREATMENT WITH DANAZOL IN FEMALE RATS
INDUCTION OF TRUE PRECOCIOUS PUBERTY BY NEONATAL TREATMENT WITH DANAZOL IN FEMALE RATS
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DOI：
10.1016/0304-3940(93)90636-y
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发表时间：
1993-07-09
影响因子：
2.5
通讯作者：
AONO, T
中科院分区：
文献类型：
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作者：
MORISHITA, H;TAKEMOTO, M;AONO, T
5日龄雌性大鼠单次皮下注射不同剂量的那那唑或对照物。300杯达那唑组大鼠阴道开放天数（37.50 +/- 0.49天，25.20 +/- 0.19天；平均+/- S.E.M.）、首次发情天数（38.19 +/- 0.62天，29.10 +/- 0.26天）和发情周期开始时间（49.63 +/- 1.30天，37.07 +/- 1.50天）均显著提前（P < 0.01）。各组大鼠成年期均以4 ~ 5 d为发情周期。5日龄大鼠经300杯达那唑处理后，在第一次发情后期排出黄体生成素。这些结果表明，新生儿给药的达纳唑会使雌性大鼠产生真正的性早熟，这种性早熟大鼠代表了分析青春期开始的独特模型。
Female rats at 5 days of age were given a single subcutaneous injection of varying doses of danazol or vehicle. Rats treated with 300 mug of danazol showed significant (P < 0.01, respectively) advancement in the day of vaginal opening (37.50 +/- 0.49 days vs. 25.20 +/- 0.19 days; mean +/- S.E.M.), first estrus (38.19 +/- 0.62 days vs. 29.10 +/- 0.26 days) and onset of estrous cycle (49.63 +/- 1.30 days vs. 37.07 +/- 1.50 days). All rats treated with danazol showed 4- or 5-day estrous cycle in the adulthood. Rats treated with 300 mug of danazol at 5 days of age discharged luteinizing hormone in the late stage of first proestrus. These results demonstrate that neonatally administered danazol produces the true precocious puberty in female rats, and this sexual precocity rat represents a unique model for analysis of the onset of puberty.