Striatal lesions produce distinctive impairments in reaction time performance in two different operant chambers
Striatal lesions produce distinctive impairments in reaction time performance in two different operant chambers
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DOI：
10.1016/s0361-9230(98)00044-6
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发表时间：
1998-08-01
影响因子：
3.8
通讯作者：
Dunnett, SB
中科院分区：
文献类型：
--
作者：
Brasted, PJ;Döbrössy, MD;Dunnett, SB
背纹状体在调节自主运动中起关键作用。在以前的研究中，老鼠的兴奋性毒性纹状体损伤被证明会损害在自动侧刺鼻装置（“九孔箱”）中选择反应时间任务的开始，但不会损害运动的执行。相反，当在传统的操作室（或“斯金纳箱”）中应用概念上相似的反应时间任务时，纹状体损伤被认为会损害执行，而不是损害侧化运动的开始。本研究通过训练同一组大鼠在两个室中执行选择反应时间任务，然后在两个室中平行比较单侧兴奋毒性纹状体损伤的影响，从而直接比较这两种结果。纹状体损伤后，大鼠在两种任务中均表现出明显的对侧损伤。然而，它们在九孔箱中表现出反应时间缺陷，而在斯金纳箱中表现出明显的反应执行缺陷。这一发现证实了之前的研究，并表明结果的差异并不仅仅归因于病变、训练条件或任务参数的程序差异，相反，纹状体病变后的反应时间缺陷模式主要取决于所使用的仪器和每个任务的精确反应要求。(C) 1998爱思唯尔科学有限公司
The dorsal striatum plays a crucial role in mediating voluntary movement. Excitotoxic striatal lesions in rats have previously been shown to impair the initiation but not the execution of movement in a choice reaction time task in an automated lateralised nose-poke apparatus (the "nine-hole box"), Conversely, when a conceptually similar reaction time task has been applied in a conventional operant chamber (or "Skinner box"), striatal lesions have been seen to impair the execution rather than the initiation of the lateralised movement. The present study was undertaken to compare directly these two results by training the same group of rats to perform a choice reaction time task in the two chambers and then comparing the effects of a unilateral excitotoxic striatal lesion in both chambers in parallel. Particular attention was paid to adopting similar parameters and contingencies in the control of the task in the two test chambers, After striatal lesions, the rats showed predominantly contralateral impairments in both tasks, However, they showed a deficit in reaction time in the nine-hole box but an apparent deficit in response execution in the Skinner box, This finding confirms the previous studies and indicates that differences in outcome are not simply attributable to procedural differences in the lesions, training conditions or tasks parameters, Rather, the pattern of reaction time deficit after striatal lesions depends critically on the apparatus used and the precise response requirements for each task. (C) 1998 Elsevier Science Inc.