Motility related protein 1 (MRP1/CD9) expression in colon cancer.
Motility related protein 1 (MRP1/CD9) expression in colon cancer.
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发表时间：
1998-06
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影响因子：
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通讯作者：
Masaki Mori;K. Mimori;T. Shiraishi;M. Haraguchi;H. Ueo;G. Barnard;T. Akiyoshi
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作者：
Masaki Mori;K. Mimori;T. Shiraishi;M. Haraguchi;H. Ueo;G. Barnard;T. Akiyoshi
重要的是检测可能是结肠癌患者良好预后标志物的基因。考虑到这一点，我们确定了运动相关蛋白-1（MRP 1/CD 9）基因在人类结肠组织。本研究旨在探讨MRP 1/CD 9基因在结肠癌中的表达及其意义。我们在结肠的肿瘤/正常配对样品之间进行了差异mRNA显示技术，并鉴定了MRP 1/CD 9。应用逆转录-聚合酶链反应（RT-PCR）技术对82例原发性结直肠癌手术标本进行MRP 1/CD 9基因检测。单因素和多因素分析其表达状态和临床病理变量。MRP 1/CD 9 mRNA表达阳性56例，阴性26例。MRP 1/CD 9阴性组的静脉血管侵犯和肝转移发生率明显高于MRP 1/CD 9阳性组（P < 0.05），且预后差。考克斯回归模型的多因素分析显示，MRP 1/CD 9表达是一个独立的预后因素不同于淋巴结状态。提示检测MRP 1/CD 9的表达对预测结直肠癌患者的预后有一定意义。
It is important to detect genes that may be good prognostic markers for colon cancer patients. With this in mind, we identified the motility related protein-1 (MRP1/CD9) gene in human colon tissues. The aim of this study was to clarify the significance of MRP1/CD9 gene expression in human colon cancers. We performed the differential mRNA display technique between tumor/normal paired samples of the colon and identified MRP1/CD9. Eighty-two surgical specimens of primary colorectal cancer were analyzed by means of reverse transcription-PCR for the MRP1/CD9 gene. Its expression status and clinicopathological variables were analyzed univariately and multivariately. The MRP1/ CD9 mRNA expression was positive in 56 cases and negative in 26 cases. The MRP1/CD9 negative cases showed a significantly higher frequency of venous-vessel invasion and liver metastasis, or a worse prognosis than the MRP1/CD9 positive cases (P < 0.05). Multivariate analysis with the Cox regression model disclosed that MRP1/CD9 expression was an independent prognostic factor distinct from the lymph node status. The findings imply that the study of MRP1/CD9 expression may be useful for predicting prognosis of patients with colorectal cancer.