3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease
3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease
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DOI：
10.1093/brain/awl274
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发表时间：
2006-11-01
期刊：
影响因子：
14.5
通讯作者：
Thompson, Paul M.
中科院分区：
文献类型：
--
作者：
Apostolova, Liana G.;Dinov, Ivo D.;Thompson, Paul M.
阿尔茨海默病是老年人最常见的神经退行性疾病。遗忘型轻度认知功能障碍（MCI）是一个相对较新定义的临床实体，需要记忆下降，而日常生活活动保持完整。大多数遗忘型MCI患者发展为阿尔茨海默病。使用一种创新的基于表面的海马分析技术，我们分析了31名遗忘型MCI和34名阿尔茨海默病患者的结构磁共振海马数据。我们检验了阿尔茨海默病受试者相对于遗忘型MCI受试者具有更大的CA1、CA2和CA3海马子区域萎缩的假设。3D海马图将主要组差异定位于双侧CA1区和右侧CA2和CA3区（左侧P = 0.0024，右侧P = 0.0002，均经多重比较校正）。年龄、种族、性别、文化程度和简易精神状态检查量表是海马体积的重要预测因素。海马体积是临床诊断的重要预测因子。我们的研究表明，随着阿尔茨海默病的进展，分区域海马萎缩的传播模式，按照已知的轨迹神经缠结传播。新的海马分析技术，可以跟踪海马病理学的传播在3D与这样的精度是一个很有前途的研究工具。
Alzheimer's disease is the most common neurodegenerative disorder in the elderly. Amnestic mild cognitive impairment (MCI) is a relatively newly defined clinical entity that requires memory decline while activities of daily living remain intact. Most amnestic MCI patients develop Alzheimer's disease. Using an innovative surface-based hippocampal analytic technique we analysed the structural magnetic resonance hippocampal data of 31 amnestic MCI and 34 Alzheimer's disease subjects. We tested the hypothesis that Alzheimer's disease subjects have greater atrophy of the CA1, CA2 and CA3 hippocampal subfields relative to amnestic MCI subjects. 3D hippocampal maps localized the main group differences to the CA1 region bilaterally and the CA2 and CA3 region on the right (left P = 0.0024, right P = 0.0002, both corrected for multiple comparisons). Age, race, gender, education and Mini-Mental State Examination were significant predictors of hippocampal volume. Hippocampal volume was a significant predictor of clinical diagnosis. Our study suggests that as Alzheimer's disease progresses, subregional hippocampal atrophy spreads in a pattern that follows the known trajectory of neurofibrillary tangle dissemination. Novel hippocampal analytic techniques that can track the spread of hippocampal pathology in 3D with such precision are a promising research tool.