A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson's Disease.
A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson's Disease.
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DOI：
10.3233/jpd-171176
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Tofaris GK
中科院分区：
文献类型：
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作者：
Tofaris GK
包括外泌体的细胞外囊泡由包括神经元在内的多种细胞类型释放，并表现出反映正常和疾病状态的分子谱。由于它们的内容代表了细胞内环境的快照，因此它们可以被利用为否则无法进入的大脑微环境的生物标志物。此外，它们可能通过促进错误折叠蛋白在远端部位的扩散或激活免疫细胞而促进神经退行性疾病的进展。本文综述了外泌体在帕金森病病理生理学及其作为疾病生物标志物的研究进展。
Extracellular vesicles including exosomes are released by a variety of cell types including neurons and exhibit molecular profiles that reflect normal and disease states. As their content represents a snapshot of the intracellular milieu, they could be exploited as biomarkers of the otherwise inaccessible brain microenvironment. In addition they may contribute to the progression of neurodegenerative disorders by facilitating the spread of misfolded proteins at distant sites or activating immune cells. This review summarizes recent advances in the study of exosomes in Parkinson’s disease pathophysiology and their potential as disease biomarkers.