ADHD and conduct disorder: an MRI study in a community sample.
ADHD and conduct disorder: an MRI study in a community sample.
复制标题
DOI：
10.3109/15622970209150624
复制
发表时间：
2002-10-01
期刊：
影响因子：
--
通讯作者：
Leonard, Christiana
中科院分区：
文献类型：
--
作者：
Bussing, Regina;Grudnik, Jennifer;Leonard, Christiana
注意缺陷多动障碍（ADHD）儿童的MRI研究一致将注意力不集中和冲动的核心缺陷归因于额-纹状体-小脑异常；然而，没有研究调查ADHD和品行障碍（CD）儿童的神经解剖学特征。这项研究调查了一个社区样本，包括12名合并亚型多动症儿童（8-12岁，7名患有乳清症）和19名年龄、性别、利手性和贫困程度相匹配的健康对照。体积测量，包括左/右不对称，通过MRI对整个大脑、尾状体和小脑蚓进行量化。在总脑容量、尾状核体积、半球不对称或尾状核不对称方面，两组间无显著差异。然而，对蚓叶的左叶和全部后上叶和下叶的测量表明，与对照组相比，单纯ADHD和共病儿童的蚓叶体积都较小。方差分析表明，单纯ADHD和共病类型之间没有显著的体积差异。长时间暴露于哌甲酯与尾状核体积有关。这些结果表明ADHD和ADHD合并CD具有相似的异常小脑形态，并且用流行病学衍生的样本重复了先前的研究。
MRI studies of children with Attention-Deficit Hyperactivity Disorder (ADHD) have consistently attributed core deficits of inattention and impulsivity to frontal-striatal-cerebellar abnormalities; however, no study has investigated the neuroanatomical characteristics of children with ADHD and Conduct Disorder (CD). This study examined a community sample of 12 children with combined subtype ADHD (aged 8-12, 7 with CD) and 19 healthy controls matched for age, gender, handedness and poverty. Volume measurements, including left/right asymmetries, were quantified from MRI of the total brain, caudate and cerebellar vermis. No significant differences in total brain volume, caudate volume, asymmetry of the hemispheres or asymmetry of the caudate were found between the groups. Measurements of the left and total posterior superior and inferior lobes of the vermis, however, indicated smaller volumes for both pure ADHD and co-morbid children compared to the controls. Analysis of variance demonstrated no significant volumetric differences between the pure ADHD and co-morbid types. Prolonged exposure to methylphenidate was associated with caudate volumes. These results suggest ADHD and ADHD co-morbid with CD have similar deviant cerebellar morphology and replicate previous studies with an epidemiologically derived sample.