Prediction of Hepatocellular Carcinoma Development by Plasma ADAMTS13 in Chronic Hepatitis B and C
Prediction of Hepatocellular Carcinoma Development by Plasma ADAMTS13 in Chronic Hepatitis B and C
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DOI：
10.1158/1055-9965.epi-11-0464
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发表时间：
2011-10-01
影响因子：
3.8
通讯作者：
Yatomi, Yutaka
中科院分区：
文献类型：
--
作者：
Ikeda, Hitoshi;Tateishi, Ryosuke;Yatomi, Yutaka
背景资料：慢性肝损伤引起伤口愈合反应，促进纤维化并最终导致肝细胞癌（HCC），其中肝星状细胞发挥重要作用。虽然肝星状细胞的血液标志物尚不清楚，但这些细胞对调节血浆具有血小板反应蛋白1型基序的去整合素样和金属蛋白酶有重要作用13方法：在慢性肝炎B或C伴或不伴HCC患者中评估血浆ADAMTS 13。结果：血浆ADAMTS 13活性与血清天冬氨酸转氨酶和丙氨酸转氨酶、肝硬度值和天冬氨酸转氨酶与血小板比率指数显著相关，与HCC的存在无关，这表明它可能反映了肝星状细胞作用导致的肝细胞损伤和随后的伤口愈合和纤维化。在对无HCC患者的三年随访期间，81例患者中有10例发生了HCC。单变量和多变量分析显示，发生HCC的患者血浆ADAMTS 13活性显著高于未发生HCC的患者，是发生HCC的显著风险因素。此外，在接受射频消融治疗的HCC患者的一年随访期间，107例患者中有55例HCC复发。血浆ADAMTS 13活性或抗原水平在HCC复发患者中显著高于那些没有HCC复发的患者，并且通过多变量分析保留为HCC复发的显著风险。结论：血浆ADAMTS 13活性和抗原水平较高是慢性肝病HCC发展的风险。影响：血浆ADAMTS 13作为肝星状细胞的潜在标志物可能有助于预测肝癌发生。癌症流行病学生物标志物Prev; 20（10）; 2204-11。(C)2011年AACR。
Background: Chronic liver injury evokes a wound healing response, promoting fibrosis and finally hepatocellular carcinoma (HCC), in which hepatic stellate cells play an important role. Although a blood marker of hepatic stellate cells is not known, those cells importantly contribute to the regulation of plasma a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS13) activity, a defect of which causes thrombotic thrombocytopenic purpura.Methods: Plasma ADAMTS13 was evaluated in chronic hepatitis B or C patients with or without HCC.Results: Plasma ADAMTS13 activity significantly correlated with serum aspartate aminotransferase and alanine aminotransferase, liver stiffness value, and aspartate aminotransferase-to-platelet ratio index, irrespective of the presence of HCC, suggesting that it may reflect hepatocellular damage and subsequent wound healing and fibrosis as a result of hepatic stellate cell action. During the three-year follow-up period for patients without HCC, it developed in 10 among 81 patients. Plasma ADAMTS13 activity was significantly higher in patients with HCC development than in those without and was a significant risk for HCC development by univariate and multivariate analyses. Furthermore, during the one-year follow-up period for patients with HCC treated with radiofrequency ablation, HCC recurred in 55 among 107 patients. Plasma ADAMTS13 activity or antigen level was significantly higher in patients with HCC recurrence than in those without and was retained as a significant risk for HCC recurrence by multivariate analysis.Conclusions: Higher plasma ADAMTS13 activity and antigen level was a risk of HCC development in chronic liver disease.Impact: Plasma ADAMTS13 as a potential marker of hepatic stellate cells may be useful in the prediction of hepatocarcinogenesis. Cancer Epidemiol Biomarkers Prev; 20(10); 2204-11. (C) 2011 AACR.