Cimetidine and visual hallucinations.

Cimetidine and visual hallucinations.
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西咪替丁和幻视。

DOI:
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发表时间:
1978
期刊:
Journal of the American Medical Association (JAMA)
影响因子:
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通讯作者:
S. K. Agarwal
S. K. Agarwal
中科院分区:
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文献类型:
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作者:
S. K. Agarwal

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致编辑。-已确认有少数使用西咪替丁导致精神错乱的病例。这在老年人摄入双倍或更高剂量或正常剂量后都可以看到。我想提请大家注意视幻觉是西咪替丁治疗可能产生的副作用。病例报告。-一名72岁男性因意识不清、头痛和呕吐入院。六周前,他头部受伤,为此他服用了地塞米松。他被发现有高血压,并给予甲基多巴和氯噻嗪治疗。CT扫描和双侧颈动脉造影显示双侧额顶叶慢性硬膜下血肿。在住院的第4天,进行了双侧开颅手术,并清除了液肿。术后患者每6小时给予地塞米松4mg,每日给予氢氧化镁30cc(美兰达)4次,苯妥英钠100mg, a次3次
To the Editor.— A few cases of mental confusion with cimetidine have been recognized. This has been seen after intake of a double or higher dose or at normal doses in older people. I wish to draw attention to visual hallucinations as a possible adverse effect of cimetidine therapy. Report of a Case.— A 72-year-old man was admitted with confusion, headache, and vomiting. He had sustained a head injury six weeks previously, for which he was given dexamethasone. He was found to be hypertensive and was treated with methyldopa and chlorothiazide. A CT scan and bilateral corotid angiograms disclosed bilateral frontoparietal chronic subdural hematomas. On the fourth hospital day a bilateral craniotomy was done, and liquified hematomas were evacuated. Postoperatively the patient was given 4 mg of dexamethasone every six hours, 30 cc of magnesium hydroxide (Mylanta) four times a day, and 100 mg of phenytoin sodium three times a