POTASSIUM ION CURRENT IN THE SQUID GIANT AXON - DYNAMIC CHARACTERISTIC
POTASSIUM ION CURRENT IN THE SQUID GIANT AXON - DYNAMIC CHARACTERISTIC
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DOI：
10.1016/s0006-3495(60)86871-3
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发表时间：
1960-01-01
影响因子：
3.4
通讯作者：
MOORE, JW
中科院分区：
文献类型：
--
作者：
COLE, KS;MOORE, JW
的测量。在将膜电位改变为Hodgkin和Huxley（HH）的钠电位之后，从接近静息电位、从各种持续时间和幅度的去极化以及从高达150 mV的超极化，在鱿鱼轴突膜中产生了钾电流。其中[image]t0由初始条件确定，钾电流I表示新数据，并在适当区域近似HH函数。钠电流的相应修改似乎没有必要。结果支持HH假设的独立性的钾和钠电流，依赖于钾电流后的膜电位确定的一个单一的参数，并表示该参数的一阶微分方程，而且，虽然结果大大修改的分析表达式，他们非常显着扩展这些假设的表观有效性的范围。严重超极化后钾电流的延迟用于估计膜中钾离子迁移率为其在水溶液中的值的10-5。
Measurements of. the potassium current in the squid axon membrane have been made, after changes of the membrane potential to the sodium potential of Hodgkin and Huxley (HH), from near the resting potential, from depolarizations of various durations and amplitudes, and from hyperpolarizations of up to 150 mv. The potassium currents I given by where [image]t0 is determined by the initial conditions, represent the new data and approximate the HH functions in the regions for which they are adequate. A corresponding modification for the sodium current does not appear necessary. The results support the HH assumptions of the independence of the potassium and sodium currents, the dependence of the potassium current upon a single parameter determined by the membrane potential, and the expression of this parameter by a first order differential equation, and, although the results drastically modify the analytical expressions, they very considerably extend the range of apparent validity of these assumptions. The delay in the potassium current after severe hyperpolarization is used to estimate a potassium ion mobility in the membrane as 10-5 of its value in aqueous solutions.