Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy
Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy
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DOI：
10.1021/nl070610y
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发表时间：
2007-07-01
期刊：
影响因子：
10.8
通讯作者：
West, Jennifer L.
中科院分区：
文献类型：
--
作者：
Gobin, Andre M.;Lee, Min Ho;West, Jennifer L.
金属纳米壳是核/壳纳米颗粒，其可以被设计为在近红外（NIR）波长区域（类似于650-950 nm）内强烈吸收或散射。纳米壳被设计为在NIR中具有吸收和散射特性，以提供光学对比度，用于改善诊断成像，并且在较高的光强度下，用于光热治疗的快速加热。在小鼠模型中使用这些，我们已经证明了光学相干断层扫描（OCT）和有效的光热消融肿瘤的显着对比度增强。
Metal nanoshells are core/shell nanoparticles that can be designed to either strongly absorb or scatter within the near-infrared (NIR) wavelength region (similar to 650-950 nm). Nanoshells were designed that possess both absorption and scattering properties in the NIR to provide optical contrast for improved diagnostic imaging and, at higher light intensity, rapid heating for photothermal therapy. Using these in a mouse model, we have demonstrated dramatic contrast enhancement for optical coherence tomography (OCT) and effective photothermal ablation of tumors.