Risk for gastric lymphoma in persons with CagA+ and CagA- Helicobacter pylori infection.
Risk for gastric lymphoma in persons with CagA+ and CagA- Helicobacter pylori infection.
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CagA 和 CagA- 幽门螺杆菌感染者患胃淋巴瘤的风险。
DOI：
10.1086/517346
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Parsonnet,J
中科院分区：
文献类型：
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作者：
Witherell,HL;Hansen,S;Jellum,E;Orentreich,N;Vogelman,JH;Parsonnet,J
感染幽门螺杆菌会增加患胃非霍奇金淋巴瘤(GNHL)的风险。表达CagA蛋白的菌株被认为是特别毒力的。确定CagA+幽门螺杆菌感染是否比CagA-感染更增加GNHL的风险。32例病例和130例对照此前进行了试验。用双抗体夹心法检测幽门螺杆菌CagA抗体。用条件Logistic回归分析比较CagA+、CagA0和非感染者之间发生GNHL的风险。CAGA/受试者患GNHL的风险是未感染者的8.2倍(95%可信区间[CI]，2.5-26.7)。CagA0受试者患GNHL的风险是未感染者的4.4倍(95%可信区间，1.2-16.5)。仅在感染人群中，与CagA0感染相比，CagA+感染与GNHL的风险增加并不相关(优势比，2.1；95%可信区间，0.8-5.4)。这项研究并不支持CagA在淋巴肿瘤发生中的重要作用。
Infection withHelicobacter pylori increases the risk for gastric non-Hodgkin's lymphoma (GNHL). Strains that express CagA protein are thought to be particularly virulent. It was determined whether CagA+H. pyloriinfection increased the risk for GNHL more than CagA-infection. Thirty-two cases and 130 controls previously tested forH. pyloriantibodies were tested for CagA antibodies by ELISA. The risk for GNHL was compared among CagA+, CagA0, and uninfected persons by use of conditional logistic regression. CagA/ subjects had 8.2 times the risk for GNHL than uninfected persons (95% confidence interval [CI], 2.5–26.7). CagA0 subjects had 4.4 times the risk for GNHL than uninfected persons (95% CI, 1.2–16.5). Among infected subjects only, CagA+infection was not associated with significantly increased risk for GNHL when compared with CagA0 infection (odds ratio, 2.1; 95% CI, 0.8–5.4). This study does not support a major role for CagA in lymphomagenesis.