Phenotypic and Molecular Evidence Suggests That Decrements in Morning and Evening Energy Are Distinct but Related Symptoms.
Phenotypic and Molecular Evidence Suggests That Decrements in Morning and Evening Energy Are Distinct but Related Symptoms.
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DOI：
10.1016/j.jpainsymman.2015.05.008
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发表时间：
2015-11
影响因子：
4.7
通讯作者：
Miaskowski C
中科院分区：
文献类型：
--
作者：
Aouizerat BE;Dhruva A;Paul SM;Cooper BA;Kober KM;Miaskowski C
关于肿瘤患者及其家庭护理人员（FC）的能量水平知之甚少。本研究试图根据自我报告的能量水平确定潜在的参与者类别，并评估这些类别之间表型和基因型特征的差异。Lee疲劳量表的能量子量表得分用于确定潜在的类别成员资格。在放射治疗完成前、放射治疗期间和放射治疗完成后4个月内获得早晨和晚上的能量评分。评估了15个促炎和抗炎细胞因子基因的遗传相关性。两个潜在的类与不同的早晨能量轨迹被确定。年轻、女性、未婚/伴侣、黑人、合并症较多、功能状态较低的参与者更有可能属于低晨间能量类。两个多态性（IL 2 rs 1479923，NFKB 1 rs 4648110）与早晨能量潜伏类成员。两个潜在的类与不同的晚上的能量轨迹被确定。年轻男性、合并症多、体重减轻、功能状态较低的参与者更有可能属于中等晚间能量类别。5种不同的多态性（IL 1 R2 rs 4141134、IL 6 rs 4719714、IL 17 A rs 8193036、NFKB 2 rs 1056890、TNFA rs 1800683）与夜间能量潜伏类别成员资格相关。这项研究提供了初步证据，即早晨和晚上能量的减少与不同的表型风险因素以及细胞因子基因变异有关。
Little is known about energy levels in oncology patients and their family caregivers (FCs). This study sought to identify latent classes of participants, based on self-reported energy levels and to evaluate for differences in phenotypic and genotypic characteristics between these classes. Energy subscale scores from the Lee Fatigue Scale were used to determine latent class membership. Morning and evening energy scores were obtained just prior to, during, and for four months following the completion of radiation therapy. Genetic associations were evaluated for fifteen pro- and anti-inflammatory cytokine genes. Two latent classes with distinct morning energy trajectories were identified. Participants who were younger, female, not married/partnered, Black, and had more comorbidities, and a lower functional status were more likely to be in the Low Morning Energy class. Two polymorphisms (IL2 rs1479923, NFKB1 rs4648110) were associated with morning energy latent class membership. Two latent classes with distinct evening energy trajectories were identified. Participants who were younger and male and who had more comorbidities, decreased body weight, and a lower functional status were more likely to be in the Moderate Evening Energy class. Five different polymorphisms (IL1R2 rs4141134, IL6 rs4719714, IL17A rs8193036, NFKB2 rs1056890, TNFA rs1800683) were associated with evening energy latent class membership. This study provides preliminary evidence that decrements in morning and evening energy are associated with different phenotypic risk factors as well as cytokine gene variations.