Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats
Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats
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DOI：
10.1016/j.regpep.2006.04.009
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发表时间：
2006-09-11
影响因子：
--
通讯作者：
Bloom, S. R.
中科院分区：
文献类型：
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作者：
McGowan, B. M.;Stanley, S. A.;Bloom, S. R.
在雄性Wistar大鼠中，研究了急性和重复脑室旁（iVN）给予人松弛素-3（H3）对摄食量、能量消耗和下丘脑-垂体-甲状腺轴的影响。H3的急性高剂量iPVN注射显著增加了给药后1小时的食物摄入[0.4 +/- 0.1 g（媒介物）相对于1.6 +/- 0.5 g（180 pmol H3）、2.4 +/- 0.5 g（540 pmol H3）和2.2 +/- 0.5 g（1620 pmol H3），所有剂量相对于媒介物p < 0.05]。与媒介物相比，重复iPVN H3注射（180 pmol/每天两次，持续7天）显著增加随意饲喂的动物中的累积食物摄入[211.8 +/-17.1 g（媒介物）对261.6 +/-6.7 g（随意饲喂H3），p < 0.05]。H3自由采食组血浆瘦素水平升高。H3急性和重复给药后，血浆促甲状腺激素显著降低。这些数据表明，H3可能在长期控制食物摄入方面发挥作用。(c)2006 Elsevier B. V.保留所有权利。
The effects of acute and repeated intraparaventricular (iPVN) administration of human relaxin-3 (H3) were examined on food intake, energy expenditure, and the hypothalamo-pituitary thyroid axis in male Wistar rats. An acute high dose iPVN injection of H3 significantly increased food intake I h post-administration [0.4 +/- 0.1 g (vehicle) vs 1.6 +/- 0.5 g (180 pmol H3), 2.4 +/- 0.5 g (540 pmol H3) and 2.2 +/- 0.5 g (1620 pmol H3), p < 0.05 for all doses vs vehicle]. Repeated iPVN H3 injection (180 pmol/twice a day for 7 days) significantly increased cumulative food intake in ad libitum fed animals compared with vehicle [211.8 +/- 17.1 g (vehicle) vs 261.6 +/- 6.7 g (ad libitum fed H3),p < 0.05]. Plasma leptin was increased in the H3 ad libitum fed group. Plasma thyroid stimulating hormone was significantly decreased after acute and repeated administration of H3. These data suggest H3 may play a role in long-term control of food intake. (c) 2006 Elsevier B.V. All rights reserved.