Notch, lipids, and endothelial cells.
Notch, lipids, and endothelial cells.
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DOI：
10.1097/mol.0000000000000337
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发表时间：
2016-10
影响因子：
4.4
通讯作者：
Iruela-Arispe ML
中科院分区：
文献类型：
--
作者：
Briot A;Bouloumié A;Iruela-Arispe ML
Notch信号通路是一种进化保守的通路，对心血管发育和血管生成至关重要。最近，Notch信号传导对成人血管系统稳态的贡献已经成为一个重要的新范式，但仍有许多有待理解。最近的研究结果揭示了Notch对微环境信号的血管和免疫反应以及动脉粥样硬化发病的影响。在过去的一年里，在人类和小鼠中的研究探索了Notch在维持非活化内皮细胞中的作用。新的证据表明，这一途径对环境因素敏感，包括炎症介质和饮食衍生的副产品。一个新的主题是Notch对微环境变化的反应能力，包括葡萄糖和脂质代谢产物。反过来，Notch的改变使代谢和转录变化之间的重要联系成为可能，因此这种受体似乎起着代谢传感器的作用，直接影响基因表达。
Notch signaling is an evolutionary conserved pathway critical for cardiovascular development and angiogenesis. More recently, the contribution of Notch signaling to the homeostasis of the adult vasculature has emerged as an important novel paradigm, but much remains to be understood. Recent findings shed light on the impact of Notch in vascular and immune responses to microenvironmental signals as well as on the onset of atherosclerosis. In the past year, studies in human and mice explored the role of Notch in the maintenance of a nonactivated endothelium. Novel pieces of evidence suggest that this pathway is sensitive to environmental factors, including inflammatory mediators and diet-derived by-products. An emerging theme is the ability of Notch to respond to changes in the microenvironment, including glucose and lipid metabolites. In turn, alterations in Notch enable an important link between metabolism and transcriptional changes, thus this receptor appears to function as a metabolic sensor with direct implications to gene expression.