Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children
Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children
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DOI：
10.1016/j.aogh.2015.12.008
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发表时间：
2015-09-01
影响因子：
2.9
通讯作者：
Rahamon, Sheu Kadiri
中科院分区：
文献类型：
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作者：
Arinola, Ganiyu Olatunbosun;Morenikeji, Olajumoke Abimbola;Rahamon, Sheu Kadiri
蠕虫感染是一个重要的健康挑战。由于对辅助性T细胞2（Th 2）的免疫应答的调节，蠕虫感染与其他疾病共存期间表现出的免疫相互作用仍然知之甚少。目的本研究确定了孕妇、学龄前儿童、方法对17名孕妇、42名学龄前儿童和60名学龄期儿童进行了寄生虫感染（HI）调查。他们与21名孕妇，42名学龄前儿童和50名学龄儿童作为对照，没有蠕虫感染（HN）。从每个参与者收集静脉血样品并分析肿瘤坏死因子a（TNF-α）、白细胞介素-10（IL-10）、白细胞介素-8（IL-8）、白细胞介素-6（IL-6）和IgE的血清水平。采用Student t检验进行统计学分析，P
BACKGROUND Helminth infection is an important health challenge. Because of modulation of the immune response toward T-helper 2 (Th2) cells, the immunologic interplay that manifest during the coexistence of helminth infection with other conditions is still poorly understood.OBJECTIVE This study determined the pattern of alteration in selected cytokines and immunoglobulin E (IgE) in pregnant women, preschool aged children, and school-aged children with helminth infection compared with uninfected groups.METHODS Seventeen pregnant women, 42 preschool-aged children, and 60 school-aged children with helminth infection (HI) were recruited into this study. They were matched with 21 pregnant women, 42 preschool-aged children, and 50 school-aged children without helminth infection (HN) who served as controls. Venous blood samples were collected from each participant and analyzed for serum levels of tumor necrosis factor a (TNF-a), interleukin-10 (IL-10), interleukin-8 (IL-8), interleukin-6 (IL-6), and IgE. Statistical analysis was done using the Student t test, and P