Catalytic role of the C-terminal domains of a fungal non-reducing polyketide synthase
Catalytic role of the C-terminal domains of a fungal non-reducing polyketide synthase
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DOI：
10.1039/c0cc01162b
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Simpson, Thomas J.
中科院分区：
文献类型：
--
作者：
Fisch, Katja M.;Skellam, Elizabeth;Simpson, Thomas J.
截短形式的甲基肉桂醛合酶的体内活性表明，该合酶在不存在还原链释放的情况下保留水解释放活性，并且链长度不受还原释放结构域控制;使用甲基转移酶抑制剂的实验表明甲基化发生在芳香化之前。
The in vivo activity of truncated forms of methylorcinaldehyde synthase shows that the synthase retains a hydrolytic release activity in the absence of reductive chain release and that chain-length is not controlled by the reductive release domain; experiments using a methyltransferase inhibitor suggest that methylation occurs prior to aromatisation.