Coupled oscillator systems of cultured cardiac myocytes: fluctuation and scaling properties.
Coupled oscillator systems of cultured cardiac myocytes: fluctuation and scaling properties.
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培养心肌细胞的耦合振荡器系统：波动和缩放特性。
DOI：
10.1103/physreve.70.021904
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
K. Kawahara
中科院分区：
文献类型：
--
作者：
M. Yoneyama;K. Kawahara
分离和培养的新生儿心肌细胞表现出自主节律性收缩，其动态变化根据各个肌细胞之间相互耦合的程度而显着变化。我们研究了自发跳动培养的新生大鼠心肌细胞聚合系统中搏动间隔序列的时间变化，并观察到丰富多样的复杂非线性特征，例如频繁交替、双稳态和周期性尖峰。区间序列的波动分析表明，随着耦合随着孵化时间的推移而发展，尺度行为会发生从持续相关性到反持续相关性的转变。此外，我们使用相互作用的 Bonhoeffer-van der Pol 振荡器进行计算机模拟，以了解耦合对每个组成振荡器的波动动力学的影响。我们发现，振子之间形成强异质耦合是产生区间级数以及标度行为复杂性的关键因素。
Isolated and cultured neonatal cardiac myocytes exhibit autonomous rhythmic contraction, and their dynamics vary dramatically depending on the extent of mutual coupling among individual myocytes. We study the temporal changes of interbeat interval series in aggregated systems of spontaneously beating cultured neonatal rat cardiac myocytes and observe a rich variety of complex, nonlinear features such as frequent alternations, bistability, and periodic spikes. Fluctuation analysis of the interval series reveals that there occurs a transition in scaling behavior from persistent correlations to antipersistent correlations as the coupling develops with incubation time. Additionally, we perform computer simulations using interacting Bonhoeffer-van der Pol oscillators to understand the effects of coupling on the fluctuation dynamics of each constituent oscillator. We find that the formation of strong and heterogeneous coupling among the oscillators is a key factor to yield the complexity in the interval series as well as in the scaling behavior.
影响因子：
2.4
作者：
Chen, Z;Ivanov, PC;Stanley, HE
通讯作者：
Stanley, HE