Sequence of galR gene indicates a common evolutionary origin of lac and gal repressor in Escherichia coli.
Sequence of galR gene indicates a common evolutionary origin of lac and gal repressor in Escherichia coli.
复制标题
galR基因的序列表明了大肠杆菌中lac和gal阻遏蛋白的共同进化起源。
DOI：
10.1073/pnas.79.8.2427
复制
发表时间：
1982
影响因子：
11.1
通讯作者：
B. Müller
中科院分区：
文献类型：
--
作者：
B. von Wilcken;B. Müller
对编码半乳糖抑制因子的大肠杆菌galR基因的核苷酸序列进行了测定。GAL抑制子的亚基预测由343个残基组成，包括NH2末端的蛋氨酸。在预测的GAL抑制子的NH2端55个残基中，有26个与Lac抑制子的NH2端残基相同。额外的同源性出现在残基165和200之间，残基235和255之间，以及残基325左右。
The nucleotide sequence of the galR gene of Escherichia coli, which codes for galactose repressor, has been determined. The subunits of gal repressor are predicted to consist of 343 residues, including the NH2-terminal methionine. Twenty-six of the predicted NH2-terminal 55 residues of gal repressor are identical to the NH2-terminal residues of lac repressor. Additional homologies appear between residues 165 and 200, between residues 235 and 255, and around residue 325.