A prospective study of risk factors for erectile dysfunction
A prospective study of risk factors for erectile dysfunction
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DOI：
10.1016/s0022-5347(06)00589-1
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发表时间：
2006-07-01
影响因子：
6.6
通讯作者：
Rimm, Eric B.
中科院分区：
文献类型：
--
作者：
Bacon, Constance G.;Mittleman, Murray A.;Rimm, Eric B.
目的：研究肥胖、体力活动、饮酒和吸烟对勃起功能障碍发生的影响。材料和方法：研究对象包括22,086名40-75岁的美国男性，他们在2000年邮寄的问卷上被要求对他们的勃起功能进行多个时期的跟踪研究。结果：在1986年前健康且勃起功能良好或非常好的男性中，17.7%的人报告在14年的随访中发生了勃起功能障碍。1986年肥胖(与理想体重男性相比，多因素相对危险度1.9，95%可信区间1.6~2.2)和吸烟(RR 1.5，95%可信区间1.3~1.7)与勃起功能障碍的风险增加相关，而体力活动(与体力活动的最高和最低五分之一相比，RR 0.7，95%CI 0.7~0.8)与勃起功能障碍的风险降低相关。对于在随访期间发生前列腺癌的男性，吸烟(RR 1.4，95%CI 1.0-1.9)是唯一与勃起功能障碍相关的生活方式因素。结论：降低勃起功能障碍的风险可能是男性参与健康促进行为的有用且尚未开发的动机。我们发现肥胖和吸烟呈正相关，而体力活动与勃起功能障碍的风险呈负相关。
Purpose: We examined the impact of obesity, physical activity, alcohol use and smoking on the development of erectile dysfunction.Materials and Methods: Subjects included 22,086 United States men 40 to 75 years old in the Health Professionals Followup, Study cohort who were asked to rate their erectile function for multiple periods on a questionnaire mailed in 2000. Men who reported good or very good erectile function and no major chronic disease before 1986 were included in the analyses.Results: Of men who were healthy and had good or very good erectile function before 1986, 17.7% reported incident erectile dysfunction during the 14-year followup. Obesity (multivariate relative risk 1.9, 95% CI 1.6-2.2 compared to men of ideal weight in 1986) and smoking (RR 1.5, 95% CI 1.3-1.7) in 1986 were associated with an increased risk of erectile dysfunction, while physical activity (RR 0.7, 95% CI 0.7- 0.8 comparing highest to lowest quintile of physical activity) was associated with a decreased risk of erectile dysfunction. For men in whom prostate cancer developed during followup, smoking (RR 1.4, 95% CI 1.0-1.9) was the only lifestyle factor associated with erectile dysfunction.Conclusions: Reducing the risk of erectile dysfunction may be a useful and to this point unexploited motivation for men to engage in health promoting behaviors. We found that obesity and smoking were positively associated, and physical activity was inversely associated with the risk of erectile dysfunction developing.