Creatine phosphate--creatine kinase in enzymatic synthesis of glycoconjugates.

Creatine phosphate--creatine kinase in enzymatic synthesis of glycoconjugates.
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磷酸肌酸 - 糖复合物酶促合成中的肌酸激酶。

DOI:
10.1021/ol034319a
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发表时间:
2003
期刊:
Organic letters.
影响因子:
--
通讯作者:
Wang,PengGeorge
Wang,PengGeorge
中科院分区:
--
文献类型:
--
作者:
Zhang,Jianbo;Wu,Bingyuan;Zhang,Yingxin;Kowal,Przemyslaw;Wang,PengGeorge

文献摘要

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Enzymatic production of glycoconjugates is hampered by expensive phosphagens such as acetyl phosphate (AcP) and phosphoenolpyruvate (PEP). Here, we introduce creatine phosphate−creatine kinase system as a novel and practical energy source in carbohydrate synthesis. This system was successfully demonstrated in the production of bioactive oligosaccharides with different sugar nucleotide regeneration systems.