Distinct Age-Related Clinical Features and Risk Assessment in Chinese With Chronic Lymphocytic Leukemia.
Distinct Age-Related Clinical Features and Risk Assessment in Chinese With Chronic Lymphocytic Leukemia.
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DOI：
10.3389/fonc.2022.885150
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发表时间：
2022
影响因子：
4.7
通讯作者：
Wang, Xin
中科院分区：
文献类型：
--
作者：
Tian, Zheng;Liu, Ming;Fang, Xiaosheng;Zhou, Xiangxiang;Li, Peipei;Li, Ying;Zhang, Lingyan;Liu, Fang;Zhang, Ya;Wang, Xin
慢性淋巴细胞白血病（CLL）的生物学和临床特征在中国人和以欧洲血统为主的患者中表现出深刻的异质性。然而，中国CLL患者的年龄相关特征和风险评估仍然不明确。目前的研究表明，CLL患者的特征是中国的发病年龄（诊断时的中位年龄：63岁）早于美国（诊断时的中位年龄：69岁）。来自山东省立医院CLL数据库的年轻患者显示出比监测、流行病学和最终结果队列更长的总生存期。此外，在中国CLL患者中，年轻患者的复发率高于老年患者。为了优化CLL患者的风险评估，开发了新的风险评分模型PR-Score和HBG-Score，分别用于预测年轻和老年CLL患者的结局。新生儿生存预测系统在评估CLL患者的总生存期和无进展生存期方面上级国际CLL预后指数（CLL-IPI）和Binet分期。这些分析强调了对不同年龄组CLL患者的风险评估的细化，为CLL的个体化诊断和治疗提供了见解。
The biological and clinical features of chronic lymphocytic leukemia (CLL) exhibited profound heterogeneity across Chinese and patients of predominately European descent. However, the age-related peculiarities and risk assessment of Chinese CLL patients remained ill-defined. The present study demonstrated that CLL patients were characterized by the earlier age at onset in China (median age at diagnosis: 63 years old) than in the United States (median age at diagnosis: 69 years old). Young patients from Shandong Provincial Hospital CLL database displayed prolonged overall survival than the Surveillance, Epidemiology, and End Results cohort. Furthermore, among Chinese CLL patients, young patients showed an increased relapse rate compared with elderly patients. To optimize the risk assessment of CLL patients, novel risk score models named PR-Score and HBG-Score were developed for predicting the outcomes of young and elderly CLL patients respectively. The neonatal survival prediction systems were superior to international prognostic index for CLL (CLL-IPI) and Binet stage in assessing the overall survival and progression free survival of CLL patients. The analyses highlighted refinement of risk evaluation for CLL patients in different age groups, providing insights into individualized diagnosis and treatment of CLL.
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