Exposing the kinetic traps in RNA folding
Exposing the kinetic traps in RNA folding
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DOI：
10.1016/s0959-440x(99)80045-1
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发表时间：
1999-06-01
影响因子：
6.8
通讯作者：
Williamson, JR
中科院分区：
文献类型：
--
作者：
Treiber, DK;Williamson, JR
与蛋白质对应物的折叠相比，大型核酶的折叠时间“缓慢”。大RNA表现出的缓慢折叠是由动力学捕获的错误折叠中间体的形成造成的，这是折叠机制的非必要特征。新开发的避免动力学捕获的突变核酶应该有助于RNA折叠问题的研究。
Large ribozymes fold on a 'glacial' timescale compared to the folding of their protein counterparts. The sluggish folding exhibited by large RNAs results from the formation of kinetically trapped, misfolded intermediates, which are nonessential features of the folding mechanism, Newly developed mutant ribozymes that avoid kinetic traps should facilitate the study of the RNA folding problem.