Induction of solid tumours in the Swiss albino mouse by low-dose foetal irradiation
Induction of solid tumours in the Swiss albino mouse by low-dose foetal irradiation
复制标题
DOI：
10.1080/095530000139050
复制
发表时间：
2000-01-01
影响因子：
2.6
通讯作者：
Hossain, M
中科院分区：
文献类型：
--
作者：
Devi, PU;Hossain, M
目的：研究产前低剂量伽马射线照射对小鼠的致瘤作用。方法和材料：怀孕的瑞士白化小鼠在妊娠第14或17天接受0.1-1.5 Gy伽马射线照射。 F-1 后代的观察直至 18 个月大。所有小鼠在 18 个月时处死，记录不同器官肿瘤的发生率。 结果：在妊娠第 14 或 17 天暴露于 0.1 至 1.5 Gy 的剂量下，成年 F-1 小鼠的肿瘤发生率呈线性二次剂量依赖性增加。受影响的主要器官是卵巢、子宫、肝脏和脾脏。在卵巢中观察到发病率最高，即使在 0.25 Gy 的情况下，也明显高于自发发病率。在其他器官中，与同一剂量的对照相比，肿瘤发生率并不显着
Purpose: To study the tumourigenic effect of prenatal low-dose gamma-irradiation in the mouse.Methods and materials: Pregnant Swiss albino mice were exposed to 0.1-1.5 Gy gamma-radiation on days 14 or 17 of gestation. The F-1 offspring were observed up to 18 months of age. All the mice were killed at 18 months and the incidence of tumours in different organs was recorded.Results: Exposure to doses from 0.1 to 1.5 Gy on days 14 or 17 of gestation produced a linear-quadratic dose-dependent increase in tumour incidence in adult F-1 mice. The main organs affected were the ovary, uterus, liver and spleen. The highest incidence was observed in the ovaries, which was significantly higher than spontaneous incidence, even at 0.25 Gy. In other organs the tumour incidence was not significant compared with controls at doses