Elevated C-reactive protein values and atherosclerosis in sudden coronary death - Association with different pathologies
Elevated C-reactive protein values and atherosclerosis in sudden coronary death - Association with different pathologies
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DOI：
10.1161/01.cir.0000015507.29953.38
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发表时间：
2002-04-30
期刊：
影响因子：
37.8
通讯作者：
Virmani, R
中科院分区：
文献类型：
--
作者：
Burke, AP;Tracy, RP;Virmani, R
背景-高敏C反应蛋白（hs-CRP）测定的血清C反应蛋白升高与不稳定冠状动脉综合征相关。有没有尸检研究相关的hs-CRP致命coronary arteries disease.Methods和Results-Postmortem血清从302尸检的男性和女性没有炎症条件以外的动脉粥样硬化进行了测定hs-CRP。有73例可归因于动脉粥样硬化血栓形成的猝死，71例稳定斑块的冠状动脉猝死，158例对照病例（非自然猝死和非心源性自然死亡，无已知升高CRP的条件）。将动脉粥样硬化分为斑块破裂（n=55）和斑块侵蚀（n=18）;估计每颗心脏的斑块负荷。总胆固醇、高密度脂蛋白胆固醇、糖尿病、吸烟史和体重指数也进行了测定。在冠状动脉死亡的患者中定量CRP的免疫组织化学染色和每个心脏的薄帽动脉粥样硬化的数量，hs-CRP在最高和最低的五分位数中。中位hs-CRP在急性破裂组为3.2 mug/mL，斑块糜烂组为2.9 mug/mL，稳定斑块组为2.5 mug/mL，对照组为1.4 mug/mL。hs-CRP平均对数在破裂组高于对照组（P
Background-Elevations in serum C-reactive protein measured by high-sensitivity assay (hs-CRP) have been associated with unstable coronary syndromes. There have been no autopsy studies correlating hs-CRP to fatal coronary artery disease.Methods and Results-Postmortem sera from 302 autopsies of men and Women without inflammatory conditions other than atherosclerosis were assayed for hs-CRP. There were 73 sudden deaths attributable to atherothrombi, 71 sudden coronary deaths with stable plaque, and 158 control cases (unnatural sudden deaths and noncardiac natural deaths without conditions known to elevate CRP). Atherothrombi were classified as plaque ruptures (n=55) and plaque erosion (n=18); plaque burden was estimated in each heart. Total cholesterol, high-density lipoprotein cholesterol, diabetes, smoking history, and body mass index were also determined. Immunohistochemical stains for CRP and numbers of thin cap atheromas per heart were quantitated in coronary deaths With hs-CRP in the highest and lowest quintiles. The median hs-CRP was 3.2 mug/mL in acute rupture, 2.9 mug/mL in plaque erosion, 2.5 mug/mL in stable plaque, and 1.4 mug/mL in controls. Mean log hs-CRP was higher in rupture (P