Extracellular matrix alterations in patients with paroxysmal and persistent atrial fibrillation
Extracellular matrix alterations in patients with paroxysmal and persistent atrial fibrillation
复制标题
DOI：
10.1016/j.jacc.2008.03.045
复制
发表时间：
2008-07-15
影响因子：
24
通讯作者：
Vardas, Panos E.
中科院分区：
文献类型：
--
作者：
Kallergis, Eleftherios M.;Manios, Emmanuel G.;Vardas, Panos E.
目的 我们研究了人类各种形式的心房颤动 (AF) 和窦性心律 (SR) 中胶原蛋白更新的血清标志物是否存在差异。背景 结构改变和纤维化与 AF 的产生和持续有关。方法 血清 I 型胶原蛋白 C 末端前肽 (CICP)、I 型胶原蛋白 C 末端端肽 (CITP)、基质金属蛋白酶-1 和基质组织抑制剂在 SR 中测量了 70 名 AF 患者和 20 名健康对照受试者的金属蛋白酶-1 作为胶原蛋白合成和降解的标志物。结果 AF 患者的 I 型胶原蛋白 C 末端前肽和 CITP 显着高于对照受试者（91 +/- 27 ng/ml vs. 67 +/- 11 ng/ml，p < 0.001 和 0.38 +/- 0.20 ng/ml vs. 0.38 +/- 0.20 ng/ml）分别为 0.25 +/- 0.08 ng/ml，p < 0.001）。与阵发性 AF 患者相比，持续性 AF 患者的 CICP 水平较高（105 +/- 28 ng/ml 对比 80 +/- 21 ng/ml，p < 0.001），但 CITP 水平较高。与阵发性 AF 患者相比，持续性 AF 患者的基质金属蛋白酶-1 水平较低，但基质金属蛋白酶-1 组织抑制剂水平升高（11.90 +/- 4.79 ng/ml 与 14.98 +/- 6.28 ng/ml，p = 0.03 和 155 +/- 45 ng/ml 与 130 +/- 38 ng/ml，p <分别为 0.001）。与阵发性和持续性 AF 患者相比，对照组受试者的基质金属蛋白酶-1 组织抑制剂水平显着较低（分别为 102 +/- 15 ng/ml、130 +/- 38 ng/ml 和 155 +/- 45 ng/ml，p < 0.001）。 结论 AF 和 SR 患者之间，I 型胶原蛋白更新的血清标志物存在显着差异。此外，这些标记物在阵发性和持续性房颤患者之间也存在显着差异，这表明细胞外 I 型胶原蛋白合成和降解的强度可能与房颤的负担或类型有关。
Objectives We investigated whether the serum markers of collagen turnover differed in various forms of atrial fibrillation (AF) and in sinus rhythm (SR) in humans.Background Structural alterations and fibrosis have been implicated in the generation and perpetuation of AF.Methods Serum C-terminal propeptide of collagen type-I (CICP), C-terminal telopeptide of collagen type- I (CITP), matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinases-1 were measured as markers of collagen synthesis and degradation in 70 patients with AF and 20 healthy control subjects in SR.Results C-terminal propeptide of collagen type-I and CITP were significantly higher in AF patients than in control subjects ( 91 +/- 27 ng/ml vs. 67 +/- 11 ng/ml, p < 0.001 and 0.38 +/- 0.20 ng/ml vs. 0.25 +/- 0.08 ng/ml, p < 0.001, respectively). Persistent AF patients had higher levels of CICP (105 +/- 28 ng/ml vs. 80 +/- 21 ng/ml, p < 0.001), but not CITP, compared with those with paroxysmal AF. Patients with persistent AF had lower levels of matrix metalloproteinase-1 but increased levels of tissue inhibitor of matrix metalloproteinases-1 compared with patients with paroxysmal AF (11.90 +/- 4.79 ng/ml vs. 14.98 +/- 6.28 ng/ml, p = 0.03 and 155 +/- 45 ng/ml vs. 130 +/- 38 ng/ml, p < 0.001, respectively). Tissue inhibitor of matrix metalloproteinases-1 levels were significantly lower in control subjects compared with those in both paroxysmal and persistent AF patients (102 +/- 15 ng/ml vs. 130 +/- 38 ng/ml vs. 155 +/- 45 ng/ml, respectively, p < 0.001).Conclusions Serum markers of collagen type- I turnover differed significantly between patients with AF and SR. Furthermore, these markers also differed significantly between paroxysmal and persistent AF patients, suggesting that the intensity of the extracellular synthesis and degradation of collagen type- I may be related to the burden or type of AF.