Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder
Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder
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DOI：
10.1016/j.jpsychires.2007.05.006
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发表时间：
2008-05-01
影响因子：
4.8
通讯作者：
Pitman, Roger K.
中科院分区：
文献类型：
--
作者：
Brunet, Alain;Orr, Scott P.;Pitman, Roger K.
在心理创伤事件发生后数小时内给予β-肾上腺素能阻滞剂心得安，可减少随后对事件进行心理想象时的生理反应。在这里，我们测试了在恢复过去创伤事件的记忆后给予心得安的效果。患有慢性创伤后应激障碍的受试者在剧本准备阶段描述了他们的创伤事件，然后接受了随机双盲的一天剂量的心得安(n=9)或安慰剂(n=10)。一周后，他们对他们的创伤事件进行剧本驱动的心理想象，同时测量心率、皮肤电导和左皱纹肌电图。在一周前接受重新激活心得安的受试者中，生理反应明显较小。在重新激活对过去创伤事件的记忆后给予普奈洛尔，以类似于在创伤事件发生后不久给予心得安的方式，减少随后对该事件的心理想象期间的生理反应。(C)2007爱思唯尔有限公司。保留所有权利。
The beta-adrenergic blocker propranolol given within hours of a psychologically traumatic event reduces physiologic responses during subsequent mental imagery of the event. Here we tested the effect of propranolol given after the retrieval of memories of past traumatic events. Subjects with chronic post-traumatic stress disorder described their traumatic event during a script preparation session and then received a one-day dose of propranolol (n = 9) or placebo (n = 10), randomized and double-blind. A week later, they engaged in script-driven mental imagery of their traumatic event while heart rate, skin conductance, and left corrugator electromyogram were measured. Physiologic responses were significantly smaller in the subjects who had received post-reactivation propranolol a week earlier. Propranolol given after reactivation of the memory of a past traumatic event reduces physiologic responding during subsequent mental imagery of the event in a similar manner to propranolol given shortly after the occurrence of a traumatic event. (c) 2007 Elsevier Ltd. All rights reserved.