HuR function in disease.
HuR function in disease.
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DOI：
10.2741/3921
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Gorospe M
中科院分区：
文献类型：
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作者：
Srikantan S;Gorospe M
控制哺乳动物基因表达的细胞质事件，主要是mRNA的稳定性和翻译，有力地影响细胞对内部和外部信号的反应。普遍存在的RNA结合蛋白（RBP）HuR是细胞质mRNA命运研究得最好的调节因子之一。通过其对特定靶mRNA的转录后影响，HuR可以改变细胞对增殖、应激、凋亡、分化、衰老、炎症和免疫刺激的反应。鉴于其在重要细胞功能中的核心作用，HuR在这些反应异常的疾病中的作用越来越受到重视。在这里，我们回顾了控制HuR功能的机制，其对靶mRNA的影响，以及HuR调控的基因表达程序的损伤如何影响不同的疾病过程。我们专注于HuR在癌症和慢性炎症中公认的意义，并讨论了将HuR与心血管，神经和肌肉病理联系起来的新兴研究。我们还讨论了治疗靶向HuR的进展，潜力和挑战。
The cytoplasmic events that control mammalian gene expression, primarily mRNA stability and translation, potently influence the cellular response to internal and external signals. The ubiquitous RNA-binding protein (RBP) HuR is one of the best-studied regulators of cytoplasmic mRNA fate. Through its post-transcriptional influence on specific target mRNAs, HuR can alter the cellular response to proliferative, stress, apoptotic, differentiation, senescence, inflammatory and immune stimuli. In light of its central role in important cellular functions, HuR’s role in diseases in which these responses are aberrant is increasingly appreciated. Here, we review the mechanisms that control HuR function, its influence on target mRNAs, and how impairment in HuR-governed gene expression programs impact upon different disease processes. We focus on HuR’s well-recognized implication in cancer and chronic inflammation, and discuss emerging studies linking HuR to cardiovascular, neurological, and muscular pathologies. We also discuss the progress, potential, and challenges of targeting HuR therapeutically.