Bat rabies in urban centers in Chile
Bat rabies in urban centers in Chile
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DOI：
10.7589/0090-3558-36.2.231
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发表时间：
2000-04-01
影响因子：
1.3
通讯作者：
de Mattos, CC
中科院分区：
文献类型：
--
作者：
de Mattos, CA;Favi, M;de Mattos, CC
对1977年至1998年间从智利家畜和食虫蝙蝠中分离到的105株狂犬病病毒的核蛋白基因进行了分子特征分析。这些分离株与从美洲已知的家庭和野生动物狂犬病宿主中分离的病毒进行了比较，以确定智利可能存在的狂犬病宿主。系统发育分析表明，没有一株智利分离株与陆源病毒分离。本研究未发现非狂犬病溶血病毒。智利的样本与拉丁美洲普通吸血蝙蝠(Desmodus Rotundus)维持的法尔法特循环病毒无关。在智利的食虫蝙蝠中发现了五种基因变异。巴西无尾蝙蝠(Tadarida Brasiliens)被确定为1977年至1998年期间该国最常见的狂犬病基因变异的宿主。家犬病毒从家犬(犬科动物)、巴西自由尾蝙蝠和红蝙蝠(北方斑腿蝙蝠)身上获得的一组病毒与斑腿蝙蝠保持的病毒密切相关。在北美，这一属的物种可能是智利这种特殊遗传变异的储藏库。其他三种变种的储存库尚不清楚。
One hundred and five rabies isolates obtained from domestic animals and insectivorous bats in Chile between 1977 and 1998 were molecularly characterized by limited sequence analysis of their nucleoprotein genes. These isolates were compared with viruses isolated from known domestic and wildlife rabies reservoirs in the Americas to identify potential reservoirs of rabies in Chile. The phylogenetic analyses showed that none of the Chilean isolates segregated with viruses from the terrestrial reservoirs. No non-rabies lyssaviruses were found in this study. The Chilean samples were not related to viruses of the sylvatic cycle maintained by the common vampire bat (Desmodus rotundus) in Latin America. Five genetic variants were identified from insectivorous bats in Chile. The Brazilian free-tailed bat (Tadarida brasiliensis) was identified as the reservoir for the rabies genetic variant most frequently isolated in the country between 1977 and 1998. The close association of a group of viruses obtained from a domestic dog (Canis familiaris), Brazilian free-tailed bats, and a red bat (Lasiurus borealis) with viruses maintained by Lasiurus spp. in North America implicated species of this genus as the possible reservoirs of this particular genetic variant in Chile. Reservoirs for the other three variants remain unknown.