ASSOCIATION BETWEEN 25-HYDROXYVITAMIN D AND INTACT PARATHYROID HORMONE LEVELS ACROSS LATITUDE AMONG ADULTS WITH AFRICAN ANCESTRY
ASSOCIATION BETWEEN 25-HYDROXYVITAMIN D AND INTACT PARATHYROID HORMONE LEVELS ACROSS LATITUDE AMONG ADULTS WITH AFRICAN ANCESTRY
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DOI：
10.4158/ep151079.or
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发表时间：
2016-08-01
影响因子：
4.2
通讯作者：
Durazo-Arvizu, Ramon
中科院分区：
文献类型：
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作者：
Kramer, Holly;Camacho, Pauline;Durazo-Arvizu, Ramon
目的：比较不同纬度的非洲裔成年人体内25-羟基维生素D(25[OH]D)水平与完整甲状旁腺激素(IPTH)水平的相关性。方法：这项研究包括生活在芝加哥、伊利诺伊州(北纬41度)、牙买加(北纬17度)、加纳(北纬6度)和南非(S度34度)4个地区的约500名非洲裔成年人。采用多元线性回归模型、非线性Logistic生长曲线模型和单结点分段线性模型，通过调整协变量，估计与iPTH停滞相关的25[OH]D水平。结果：平均年龄34.7(SD 6.2)岁，男性占46.5%。在每个地点，iPTH水平<gt；=65pg/ml的参与者在女性中的百分比高于男性，在南非女性中最常见(17.1%)，在牙买加男性中最低(0.6%)。拟合优度检验支持线性回归作为iPTH与25[OH]D水平相关的4个部位中iPTH和25[OH]D之间关联的首选模型。25[OH]D与iPTH的关联斜率因纬度不同而不同；美国最强(β=-0.81；95%可信区间[CI]=-1.03，-0.59)，牙买加最弱(β=-0.45；95%CI-0.71，-0.18)，但斜率差异较小。结论：在非洲血统的成年人中，25[OH]D与iPTH的关联呈线性关系，无论纬度在25[OH]D水平10至60 ng/mL的范围内。
Objective: To compare levels of 25-hydroxyvitamin D (25[OH]D) associated with a plateauing of intact parathyroid (iPTH) across latitudes among adults with African ancestry.Methods: This study included approximately 500 adults of African ancestry ages 25 to 45 years living in 4 sites: Chicago, Illinois (41 degrees N), Jamaica (17 degrees N), Ghana (6 degrees N), and South Africa (34 degrees S). Multivariate linear regression models, a nonlinear logistic growth curve model, and piecewise linear models with a single knot were fitted to estimate the 25[OH]D level associated with a plateauing of iPTH with adjustment for covariates. Goodness of fit was compared using computer intensive permutation tests.Results: Mean age was 34.7 (SD 6.2) years, and 46.5% were male. Within each site, the percentage of participants with an iPTH level >= 65 pg/mL was higher among females versus males and was most frequent among South African females (17.1%) and lowest among Jamaican males (0.6%). Goodness of fit tests supported linear regression as the preferred model for the association between iPTH and 25[OH]D in the 4 sites with no 25[OH]D level associated with iPTH plateauing in any site. The slope of the association between 25[ OH] D and iPTH differed by latitude; it was strongest in the U.S. (beta = -0.81; 95% confidence interval [CI] = -1.03, -0.59), and weakest in Jamaica (beta = -0.45; 95% CI -0.71, -0.18) with covariate adjustment, but differences in slopes were small.Conclusion: The association between 25[ OH] D and iPTH appears linear among adults with African ancestry regardless of latitude within a range of 25[ OH] D levels between 10 and 60 ng/mL.