Effect of stomach motility on food hydrolysis and gastric emptying: Insight from computational models
Effect of stomach motility on food hydrolysis and gastric emptying: Insight from computational models
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DOI：
10.1063/5.0120933
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发表时间：
2022-11-01
影响因子：
4.6
通讯作者：
Mittal, Rajat
中科院分区：
文献类型：
--
作者：
Kuhar, Sharun;Lee, Jae Ho;Mittal, Rajat
胃壁的蠕动运动与消化酶的分泌相结合，启动分解食物的过程。在这项研究中，混合，分解和排空的液体膳食含有蛋白质模拟在一个模型的人胃。在该模型中，胃蛋白酶（负责蛋白质水解的胃酶）从胃壁的近端区域分泌，并允许与胃内容物反应。由蠕动运动，排空率，和水解的程度引起的逆行射流的速度进行量化的控制情况下，以及其他三种情况下，减少胃的运动，这可能会导致如糖尿病的条件。这项研究量化了胃动力对食物分解率及其排空到十二指肠的影响，我们将这些观察结果与胃壁运动引起的混合相关联。
The peristaltic motion of stomach walls combines with the secretion of digestive enzymes to initiate the process that breaks down food. In this study, the mixing, breakdown, and emptying of a liquid meal containing protein is simulated in a model of a human stomach. In this model, pepsin, the gastric enzyme responsible for protein hydrolysis, is secreted from the proximal region of the stomach walls and allowed to react with the contents of the stomach. The velocities of the retropulsive jet induced by the peristaltic motion, the emptying rate, and the extent of hydrolysis are quantified for a control case as well as for three other cases with reduced motility of the stomach, which may result from conditions such as diabetes mellitus. This study quantifies the effect of stomach motility on the rate of food breakdown and its emptying into the duodenum and we correlate these observations with the mixing in the stomach induced by the wall motion.