Long-term effects of bezafibrate on in vivo VLDL-triglyceride production in the rat.
Long-term effects of bezafibrate on in vivo VLDL-triglyceride production in the rat.
复制标题
苯扎贝特对大鼠体内 VLDL-甘油三酯产生的长期影响。
DOI：
10.1016/0168-8227(90)90108-6
复制
发表时间：
1990
影响因子：
5.1
通讯作者：
S. Baba
中科院分区：
文献类型：
--
作者：
T. Kazumi;G. Yoshino;M. Iwai;K. Matsuba;M. Matsushita;I. Iwatani;T. Kasama;M. Yoshida;S. Baba
研究了苯扎贝特对大鼠体内产生极低密度脂蛋白甘油三酯的长期影响。每天服用苯扎贝特30毫克/公斤体重，连续服用14天，不仅甘油三酯下降了51%，胆固醇和磷脂也下降了28%和18%。尽管血浆甘油三酯浓度显著降低，但苯扎贝特组和对照组动物的极低密度脂蛋白-甘油三酯从肝脏分泌到循环的速率没有显著变化(分别为1113±58和1234±63ming/μ)。此外，苯扎贝特对极低密度脂蛋白的脂质成分没有影响。这些结果表明，苯扎贝特可增强甘油三酯从循环中的清除，从而导致血浆甘油三酯的降低。
Long-term effects of bezafibrate on in vivo production of VLDL-triglyceride were studied in the rat. Bezafibrate given at a daily dose of 30 mg/kg body weight for 14 days produced a decrease not only in triglyceride by 51% but in cholesterol by 28% and phospholipid by 18%. Despite a marked reduction in plasma triglyceride concentrations, there was no significant change in the rate of VLDL-triglyceride secretion from the liver into the circulation between bezafibrate-treated and control animals (1113 ± 58 and 1234 ± 63 μg/min, respectively). In addition, bezafibrate produced no change in lipid composition in VLDL. These results suggest that bezafibrate enhances triglyceride removal from the circulation, which leads to reduction in plasma triglyceride.