Auditory cortical receptive fields: Stable entities with plastic abilities
Auditory cortical receptive fields: Stable entities with plastic abilities
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DOI：
10.1523/jneurosci.1462-07.2007
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发表时间：
2007-09-26
影响因子：
5.3
通讯作者：
Shamma, Shihab A.
中科院分区：
文献类型：
--
作者：
Elhilali, Mounya;Fritz, Jonathan B.;Shamma, Shihab A.
为了形成一个可靠的，一致的，准确的声音场景的表示，一个合理的推测是，皮层神经元保持稳定的感受野后，早期的发育可塑性。然而，最近的研究表明，皮质神经元可以在整个成年期进行修改，并可能会迅速改变其响应特性，以反映某些感觉特征的行为显着性变化。由于自适应感受野可塑性的说法可能会被感受野本身内在的、不稳定的特性所混淆，我们试图测量听觉皮层神经元反应的自发变化。在本研究中，我们研究了一系列的spectrotemporal感受野（STRFs）的变化，收集从单个神经元在连续的录音中获得的时间尺度为30-120分钟的初级听觉皮层（A1）在静止，清醒的雪貂。我们使用了基于A1感受野的大型数据库的STRF形状的全球分析。通过以数据驱动的方式对该STRF空间进行聚类，STRF序列可以被分类为稳定的或不稳定的。我们发现，超过73%的A1神经元在这些时间尺度上表现出稳定的感受野属性。此外，我们发现，在静止状态下的STRF的内在变化的程度是微不足道的相比，行为引起的STRF的变化，在性能的频谱听觉任务。我们的研究结果证实，任务相关的变化引起的注意力集中在特定的声学特征确实局限于行为显着的声学线索，可以令人信服地归因于学习诱导的可塑性相比，“自发”的感受野变异。
To form a reliable, consistent, and accurate representation of the acoustic scene, a reasonable conjecture is that cortical neurons maintain stable receptive fields after an early period of developmental plasticity. However, recent studies suggest that cortical neurons can be modified throughout adulthood and may change their response properties quite rapidly to reflect changing behavioral salience of certain sensory features. Because claims of adaptive receptive field plasticity could be confounded by intrinsic, labile properties of receptive fields themselves, we sought to gauge spontaneous changes in the responses of auditory cortical neurons. In the present study, we examined changes in a series of spectrotemporal receptive fields (STRFs) gathered from single neurons in successive recordings obtained over time scales of 30-120 min in primary auditory cortex (A1) in the quiescent, awake ferret. We used a global analysis of STRF shape based on a large database of A1 receptive fields. By clustering this STRF space in a data-driven manner, STRF sequences could be classified as stable or labile. We found that > 73% of A1 neurons exhibited stable receptive field attributes over these time scales. In addition, we found that the extent of intrinsic variation in STRFs during the quiescent state was insignificant compared with behaviorally induced STRF changes observed during performance of spectral auditory tasks. Our results confirm that task-related changes induced by attentional focus on specific acoustic features were indeed confined to behaviorally salient acoustic cues and could be convincingly attributed to learning-induced plasticity when compared with "spontaneous" receptive field variability.